{"doi":"10.1002/hed.27944","title":"<scp><i>CYLD</i></scp> Alterations Are Associated With Metastasis and Poor Prognosis in Human Papilloma Virus‐Positive Head and Neck Cancer","abstract":"BACKGROUND: Human papilloma virus (HPV)-associated head and neck squamous cell carcinoma (HNSCC) is an emerging epidemic and a subset of HPV-positive patients experience aggressive disease with metastases. The CYLD gene is frequently altered in HPV-positive HNSCC, but the role of these alterations in disease progression is poorly understood. METHODS: We identified 11 HPV-positive HNSCC patients with CYLD alterations and assessed their clinical course. We also characterized a unique, HPV-positive, metastatic, HNSCC patient-derived xenograft (PDX). RESULTS: All 11 patients developed metastasis with reduced overall survival when compared with metastatic HPV-positive patients with wild-type CYLD. The metastatic PDX harbored a CYLD mutation (S371*) and exhibited reduced expression of connexin 43, a potentially antimetastatic protein. We also investigated the functional impact of the S371* mutation, as well as 2 CYLD mutations from our 11-patient cohort. CONCLUSION: Our findings indicate that alterations in CYLD in HPV-positive HNSCC are associated with metastasis and poor prognosis.","journal":"Head & Neck","year":2024,"id":474166,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8913,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":484295,"name":"Hyunseok Kang","orcid":"0000-0001-5758-8202","position":1,"is_corresponding":false},{"id":877462,"name":"Hua Li","orcid":"0000-0002-1990-6799","position":2,"is_corresponding":false},{"id":1310757,"name":"Eliot D. Lee","orcid":null,"position":3,"is_corresponding":false},{"id":1310374,"name":"Yoon Se Lee","orcid":"0000-0001-6534-5753","position":4,"is_corresponding":false},{"id":877464,"name":"Christopher N. Peterson","orcid":"0000-0002-8822-3588","position":5,"is_corresponding":false},{"id":795283,"name":"Steven Long","orcid":"0000-0001-9629-4872","position":6,"is_corresponding":false},{"id":94214,"name":"Jennifer R. Grandis","orcid":"0000-0002-1013-8965","position":7,"is_corresponding":false},{"id":103784,"name":"Daniel E. Johnson","orcid":"0000-0003-2505-530X","position":8,"is_corresponding":false},{"id":357386,"name":"Zhibin Cui","orcid":null,"position":0,"is_corresponding":true}],"reference_count":23,"raw_metadata":null,"created_at":"2026-07-19T02:06:09.108857Z","pmid":"39347568","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}