{"doi":"10.1002/hed.27604","title":"Cardiovascular events after cancer immunotherapy as oncologic emergencies: Analyses of 610 head and neck cancer patients treated with immune checkpoint inhibitors","abstract":"BACKGROUND: Cardio-oncology and emergency medicine are closely collaborative, as many cardiac events in cancer patients require evaluation and treatment in the emergency department (ED). Immune checkpoint inhibitors (ICIs) have become a common treatment for patients with head and neck cancer (HNC). However, the immune-related adverse events (irAEs) from ICIs can be clinically significant. METHODS: We reviewed and analyzed cardiovascular diagnoses among HNC patients who received ICI during the period April 1, 2016-December 31, 2020 in a large tertiary cancer center. Demographics, clinical and cancer-related data were abstracted, and billing databases were queried for cardiovascular disease (CVD)-related diagnosis using International Classification of Disease-version10 (ICD-10) codes. We recorded receipt of care at the ED as one of the outcome variables. RESULTS: A total of 610 HNC patients with a median follow-up time of 12.3 months (median, interquartile range = 5-30 months) comprised our study cohort. Overall, 25.7% of patients had pre-existing CVD prior to ICI treatment. Of the remaining 453 patients without pre-existing CVD, 31.5% (n = 143) had at least one CVD-related diagnosis after ICI initiation. Tachyarrhythmias (91 new events) was the most frequent CVD-related diagnosis after ICI. The time to diagnosis of myocarditis from initiation of ICI occurred the earliest (median 2.5 months, 1.5-6.8 months), followed by myocardial infarction (3.7, 0.5-9), cardiomyopathy (4.5, 1.6-7.3), and tachyarrhythmias (4.9, 1.2-11.4). Patients with myocarditis and tachyarrhythmias mainly presented to the ED for care. CONCLUSION: The use of ICI in HNC is still expanding and the spectrum of delayed manifestation of ICI-induced cardiovascular toxicities is yet to be fully defined in HNC survivors.","journal":"Head & Neck","year":2023,"id":350674,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":10,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.968,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":434204,"name":"Aiham Qdaisat","orcid":"0000-0003-0063-8461","position":1,"is_corresponding":false},{"id":244404,"name":"Renata Ferrarotto","orcid":"0000-0002-3561-215X","position":2,"is_corresponding":false},{"id":1095068,"name":"Anecita Fadol","orcid":"0000-0001-8779-4787","position":3,"is_corresponding":false},{"id":765846,"name":"Jason J. Bischof","orcid":"0000-0001-5950-130X","position":4,"is_corresponding":false},{"id":736193,"name":"Christopher J. Coyne","orcid":"0000-0003-2467-3800","position":5,"is_corresponding":false},{"id":519276,"name":"Demis N. Lipe","orcid":"0000-0003-2037-3085","position":6,"is_corresponding":false},{"id":435040,"name":"Ehab Y. Hanna","orcid":null,"position":7,"is_corresponding":false},{"id":105132,"name":"Sanjay Shete","orcid":"0000-0001-7622-376X","position":8,"is_corresponding":false},{"id":449040,"name":"Jun‐ichi Abe","orcid":"0000-0001-7439-7774","position":9,"is_corresponding":false},{"id":434206,"name":"Sai‐Ching J. Yeung","orcid":"0000-0001-5170-0822","position":10,"is_corresponding":false},{"id":447287,"name":"Cielito C. Reyes‐Gibby","orcid":"0000-0003-4500-6476","position":0,"is_corresponding":true}],"reference_count":48,"raw_metadata":null,"created_at":"2026-07-19T01:12:37.409066Z","pmid":"38151809","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}