{"doi":"10.1002/hed.27502","title":"Impact of comorbidities on outcomes in patients with advanced head and neck cancer undergoing immunotherapy","abstract":"OBJECTIVES: To explore the impact of pre-existing comorbidities on immunotherapy response, overall and progression-free survival, and immune-related adverse events (irAEs) of patients with advanced head and neck cancer (HNC) treated with immunotherapy. PATIENTS AND METHODS: Ninety-three patients treated with immunotherapy were identified and stratified into comorbidity absent or present (CCI < 1 and CCI ≥ 1, respectively) cohorts, and clinical outcomes were compared between these two groups. RESULTS: Patients with no comorbidities had longer overall survival (aHR = 2.74, 95% CI [1.18, 6.40], p = 0.02) and progression-free survival (aHR = 2.07, 95% CI [1.03, 4.16], p = 0.04) and a higher tumor response rate (32% in CCI < 1 vs. 14% in CC ≥ 1, p = 0.05). Risk for irAEs was higher in the comorbidity absent group (p = 0.05). CONCLUSION: Comorbidity should be considered as a significant prognostic factor in clinical decision-making for patients with advanced HNC undergoing immunotherapy.","journal":"Head & Neck","year":2023,"id":350059,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":10,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.7923,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1093984,"name":"Dylan J. Cooper","orcid":"0000-0001-8511-8371","position":1,"is_corresponding":false},{"id":1093985,"name":"Hosam H. Alkhatib","orcid":"0000-0003-0186-4532","position":2,"is_corresponding":false},{"id":1094569,"name":"Aditya Suru","orcid":null,"position":3,"is_corresponding":false},{"id":1094570,"name":"Angelo Blancaflor","orcid":null,"position":4,"is_corresponding":false},{"id":1093986,"name":"Christopher A. Maroun","orcid":"0000-0002-6941-5672","position":5,"is_corresponding":false},{"id":914209,"name":"Tristan Tham","orcid":"0000-0002-5928-762X","position":6,"is_corresponding":false},{"id":858535,"name":"Hailey Allen","orcid":null,"position":7,"is_corresponding":false},{"id":1094571,"name":"Eden Mazzara","orcid":null,"position":8,"is_corresponding":false},{"id":1033741,"name":"Jerin Thomas","orcid":"0000-0001-8420-7188","position":9,"is_corresponding":false},{"id":1093987,"name":"Neha Amin","orcid":"0000-0001-7026-8887","position":10,"is_corresponding":false},{"id":1094572,"name":"Evan Wu","orcid":null,"position":11,"is_corresponding":false},{"id":878234,"name":"David W. Eisele","orcid":"0000-0003-4003-9439","position":12,"is_corresponding":false},{"id":24637,"name":"Carole Fakhry","orcid":"0000-0002-5251-6178","position":13,"is_corresponding":false},{"id":59439,"name":"Drew M. Pardoll","orcid":"0000-0001-6215-1013","position":14,"is_corresponding":false},{"id":570227,"name":"Tanguy Y. Seiwert","orcid":"0000-0001-7919-8272","position":15,"is_corresponding":false},{"id":1093988,"name":"Gangcai Zhu","orcid":"0000-0002-7347-3816","position":16,"is_corresponding":false},{"id":244691,"name":"Rajarsi Mandal","orcid":"0000-0001-6503-5966","position":17,"is_corresponding":false},{"id":1093983,"name":"Meytal Guller","orcid":"0000-0002-5747-8211","position":0,"is_corresponding":true}],"reference_count":26,"raw_metadata":null,"created_at":"2026-07-19T01:12:23.769679Z","pmid":"37682116","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}