{"doi":"10.1002/hed.27476","title":"Prevalence of pituitary hormone dysfunction following radiotherapy for sinonasal and nasopharyngeal malignancies","abstract":"BACKGROUND: There are limited studies and no surveillance protocols on pituitary dysfunction for adults who underwent anterior skull base radiation. METHODS: Cross-sectional study of 50 consecutive patients with sinonasal or nasopharyngeal cancer who underwent definitive radiotherapy. The mean radiation doses, prevalence of pituitary dysfunction, and associated factors were calculated. RESULTS: Pituitary hormone levels were abnormal in 23 (46%) patients, including 6 (12%) with symptomatic abnormalities requiring treatment. The most common hormonal abnormality was hyperprolactinemia (30%), central hypothyroidism (8%) and central hypogonadism (6%). Patients with abnormal pituitary hormone values received higher mean radiation doses to the pituitary gland (1143 cGy, P = 0.04), pituitary stalk (1129 cGy, P = 0.02), optic chiasm (1094 cGy, P = 0.01), and hypothalamus (900 cGy, P = 0.01). CONCLUSIONS: Nearly half of the patients had abnormal pituitary function, including over a tenth requiring treatment. There may be a dose-dependent association between hormonal dysfunction and radiation.","journal":"Head & Neck","year":2023,"id":375258,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8514,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":351187,"name":"Jack Phan","orcid":"0000-0001-5977-6004","position":1,"is_corresponding":false},{"id":296141,"name":"Steven G. Waguespack","orcid":"0000-0003-0280-0100","position":2,"is_corresponding":false},{"id":1137464,"name":"Mohammed Aldehaim","orcid":"0009-0004-6470-3589","position":3,"is_corresponding":false},{"id":1137465,"name":"Xin Wang","orcid":"0000-0002-6969-6152","position":4,"is_corresponding":false},{"id":406337,"name":"Tze Yee Lim","orcid":"0000-0002-3397-5571","position":5,"is_corresponding":false},{"id":1137466,"name":"Dianna Roberts","orcid":"0000-0003-1414-1878","position":6,"is_corresponding":false},{"id":295555,"name":"Clifton D. Fuller","orcid":"0000-0002-5264-3994","position":7,"is_corresponding":false},{"id":258979,"name":"Michael T. Spiotto","orcid":"0000-0003-4484-462X","position":8,"is_corresponding":false},{"id":823496,"name":"Shaan M. Raza","orcid":"0000-0003-2722-2781","position":9,"is_corresponding":false},{"id":823497,"name":"Franco DeMonte","orcid":"0000-0002-6488-3645","position":10,"is_corresponding":false},{"id":435040,"name":"Ehab Y. Hanna","orcid":null,"position":11,"is_corresponding":false},{"id":372234,"name":"Shirley Y. Su","orcid":"0000-0002-3903-8204","position":12,"is_corresponding":false},{"id":1137463,"name":"Kevin J. Contrera","orcid":"0000-0002-2570-1706","position":0,"is_corresponding":true}],"reference_count":33,"raw_metadata":null,"created_at":"2026-07-19T01:16:19.336238Z","pmid":"37534890","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}