{"doi":"10.1002/hed.27463","title":"Neoadjuvant chemotherapy enhances tumor‐specific T cell immunity in patients with <scp>HPV</scp>‐associated oropharyngeal cancer","abstract":"BACKGROUND: Treatment of patients with newly diagnosed HPV-associated oropharyngeal squamous cell carcinoma (OPSCC) with neoadjuvant chemotherapy (NAC) results in a high rate of 5-year recurrence free survival with few patients requiring adjuvant treatment. We hypothesized that NAC enhances primary tumor HPV-specific T cell responses. METHODS: HPV-specific responses in tumor infiltrating lymphocytes (TILs) before and after NAC were determined using autologous co-culture assays. RESULTS: Greater HPV16-specific TIL responses, sometimes polyclonal, were observed after NAC compared to before in 8 of 10 patients (80%) with PCR-verified HPV16-positive tumors. A significant association was observed between net-negative change in HPV-specific TIL response and disease relapse (p = 0.04, Mann-Whitney test), whereas pathologic complete response at time of surgery did not correlate with recurrence. CONCLUSIONS: NAC induces HPV-specific tumor T cell responses in patients with newly diagnosed HPV-associated OPSCC; whereas lack of an increase following NAC may associate with risk of relapse.","journal":"Head & Neck","year":2023,"id":352826,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9646,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":322332,"name":"Jay Friedman","orcid":"0009-0008-3063-3606","position":1,"is_corresponding":false},{"id":1098684,"name":"Xinping Yang","orcid":"0000-0003-3133-4209","position":2,"is_corresponding":false},{"id":739797,"name":"Christopher Badger","orcid":"0000-0002-3714-0272","position":3,"is_corresponding":false},{"id":1098685,"name":"Timothy B. Shaver","orcid":"0000-0002-7769-6718","position":4,"is_corresponding":false},{"id":1098686,"name":"Shabnam Samankan","orcid":"0000-0002-4924-0393","position":5,"is_corresponding":false},{"id":334900,"name":"Punam Thakkar","orcid":"0000-0002-5586-0273","position":6,"is_corresponding":false},{"id":1098687,"name":"Joseph Goodman","orcid":"0000-0002-4639-3757","position":7,"is_corresponding":false},{"id":755702,"name":"Arjun S. Joshi","orcid":"0000-0002-9501-9067","position":8,"is_corresponding":false},{"id":260382,"name":"Clint Allen","orcid":"0000-0001-6586-5804","position":9,"is_corresponding":false},{"id":1099095,"name":"Christian Samaniego","orcid":null,"position":0,"is_corresponding":true}],"reference_count":29,"raw_metadata":null,"created_at":"2026-07-19T01:12:54.209378Z","pmid":"37480219","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}