{"doi":"10.1002/hed.27078","title":"Intraoperative delineation of p16+ oropharyngeal carcinoma of unknown primary origin with fluorescence lifetime imaging: Preliminary report","abstract":"BACKGROUND: This study evaluated whether fluorescence lifetime imaging (FLIm), coupled with standard diagnostic workups, could enhance primary lesion detection in patients with p16+ head and neck squamous cell carcinoma of the unknown primary (HNSCCUP). METHODS: FLIm was integrated into transoral robotic surgery to acquire optical data on six HNSCCUP patients' oropharyngeal tissues. An additional 55-patient FLIm dataset, comprising conventional primary tumors, trained a machine learning classifier; the output predicted the presence and location of HNSCCUP for the six patients. Validation was performed using histopathology. RESULTS: Among the six HNSCCUP patients, p16+ occult primary was surgically identified in three patients, whereas three patients ultimately had no identifiable primary site in the oropharynx. FLIm correctly detected HNSCCUP in all three patients (ROC-AUC: 0.90 ± 0.06), and correctly predicted benign oropharyngeal tissue for the remaining three patients. The mean sensitivity was 95% ± 3.5%, and specificity 89% ± 12.7%. CONCLUSIONS: FLIm may be a useful diagnostic adjunct for detecting HNSCCUP.","journal":"Head & Neck","year":2022,"id":249879,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":27,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9261,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":289209,"name":"Andrew C. Birkeland","orcid":"0000-0003-2500-2857","position":1,"is_corresponding":false},{"id":289204,"name":"Mark Marsden","orcid":"0000-0002-8480-9653","position":2,"is_corresponding":false},{"id":890747,"name":"Athena K. Tam","orcid":"0000-0001-6166-2487","position":3,"is_corresponding":false},{"id":289206,"name":"Julien Bec","orcid":"0000-0003-1222-4071","position":4,"is_corresponding":false},{"id":890748,"name":"Roberto P. Frusciante","orcid":"0000-0001-9305-9922","position":5,"is_corresponding":false},{"id":890749,"name":"Dorina Gui","orcid":"0000-0002-1500-6689","position":6,"is_corresponding":false},{"id":289211,"name":"Arnaud F. Bewley","orcid":"0000-0002-1524-1806","position":7,"is_corresponding":false},{"id":289210,"name":"Marianne Abouyared","orcid":"0000-0002-2779-5494","position":8,"is_corresponding":false},{"id":289213,"name":"Laura Marcu","orcid":"0000-0003-2369-0748","position":9,"is_corresponding":false},{"id":289212,"name":"D. Gregory Farwell","orcid":"0000-0003-3421-4202","position":10,"is_corresponding":false},{"id":289205,"name":"Brent W. Weyers","orcid":"0000-0002-1939-3401","position":0,"is_corresponding":true}],"reference_count":45,"raw_metadata":null,"created_at":"2026-07-19T00:24:23.754337Z","pmid":"35511208","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}