{"doi":"10.1002/hed.27040","title":"The association between inflammatory biomarkers and statin use among patients with head and neck squamous cell carcinoma","abstract":"BACKGROUND: Tumor-infiltrating lymphocytes (TILs) and cytokines are associated with prognosis among patients with head and neck squamous cell carcinoma (HNSCC). Statins (cholesterol-lowering drugs) may improve HNSCC prognosis, particularly in human papillomavirus (HPV)-positive cases, but the mechanism remains unclear. METHODS: Statin use was collected from medical records for HNSCC cases (2008-2014). TILs were counted in tumor tissue, and a total weighted score (TILws) was created. Cytokines were measured in blood. The associations between statins and biomarkers were estimated using logistic (biomarker categories: <median, ≥median) and linear regression models (log-transformed continuous biomarkers) adjusted for age, smoking, and comorbidities. RESULTS: We observed a positive association between statins and TILs among HPV-positive patients (TILws odds ratio [OR] = 2.80; 95% CI = 1.03-7.61), but no association among HPV-negative patients. We observed no association between statins and cytokines. CONCLUSIONS: Statins may influence TILs in HPV-positive patients. This may be the mechanism through which they improve prognosis in HPV-positive HNSCC patients.","journal":"Head & Neck","year":2022,"id":268233,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8652,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":453229,"name":"Emily L. Bellile","orcid":"0000-0003-4350-4658","position":1,"is_corresponding":false},{"id":365142,"name":"Katie R. Zarins","orcid":null,"position":2,"is_corresponding":false},{"id":304744,"name":"Steven B. Chinn","orcid":"0000-0003-4282-0640","position":3,"is_corresponding":false},{"id":65767,"name":"Jeremy M. G. Taylor","orcid":"0000-0003-2791-1229","position":4,"is_corresponding":false},{"id":70266,"name":"Laura S. Rozek","orcid":"0000-0001-6731-7000","position":5,"is_corresponding":false},{"id":70267,"name":"Gregory T. Wolf","orcid":"0000-0002-3219-9515","position":6,"is_corresponding":false},{"id":422749,"name":"Alison M. Mondul","orcid":"0000-0002-8843-1416","position":7,"is_corresponding":false},{"id":484825,"name":"Kayla R. Getz","orcid":"0000-0001-5552-044X","position":0,"is_corresponding":true}],"reference_count":39,"raw_metadata":null,"created_at":"2026-07-19T00:27:10.233250Z","pmid":"35338544","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}