{"doi":"10.1002/hed.26914","title":"Hyperintensity of <scp>integrin‐targeted</scp> fluorescence agent <scp>IntegriSense750</scp> accurately predicts flap necrosis compared to Indocyanine green","abstract":"BACKGROUND: Flap necrosis is a feared complication of reconstructive surgery. Current methods of prediction using Indocyanine green (ICG) lack specificity. IntegriSense750 is a fluorescence agent that binds sites of vascular remodeling. We hypothesized that IntegriSense750 better predicts flap compromise compared to ICG. METHODS: Fifteen mice underwent lateral thoracic artery axial flap harvest. Mice received an injection of ICG (n = 7) or IntegriSense750 (n = 8) daily from postoperative days (POD) 0-3 and were imaged daily. Mean signal-to-background ratios quantified the change in fluorescence as necrosis progressed. RESULTS: Mean signal-to-background ratio was significantly higher for IntegriSense750 compared to ICG on POD0 (1.47 ± 0.17 vs. 0.86 ± 0.21, p = 0.01) and daily through POD3 (2.12 ± 0.70 vs. 0.96 ± 0.29, p < 0.001). CONCLUSIONS: IntegriSense750 demonstrates increased signal-to-background ratio at areas of flap distress compared to ICG which may increase identification of flap necrosis and improve patient outcomes.","journal":"Head & Neck","year":2021,"id":212316,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9295,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":803045,"name":"Alyssa K. Ovaitt","orcid":null,"position":1,"is_corresponding":false},{"id":802616,"name":"Jason C. Fleming","orcid":"0000-0001-7963-1224","position":2,"is_corresponding":false},{"id":430672,"name":"Anna G. Sorace","orcid":"0000-0002-3640-3966","position":3,"is_corresponding":false},{"id":430667,"name":"Patrick N. Song","orcid":"0000-0002-1545-0886","position":4,"is_corresponding":false},{"id":430668,"name":"Ameer Mansur","orcid":"0009-0005-3750-7141","position":5,"is_corresponding":false},{"id":802617,"name":"Yolanda E. Hartman","orcid":"0009-0005-0948-6101","position":6,"is_corresponding":false},{"id":270918,"name":"Eben L. Rosenthal","orcid":"0000-0003-0294-5203","position":7,"is_corresponding":false},{"id":385405,"name":"Jason M. Warram","orcid":"0000-0001-5230-0011","position":8,"is_corresponding":false},{"id":802618,"name":"Carissa M. Thomas","orcid":"0000-0003-0765-5731","position":9,"is_corresponding":false},{"id":443331,"name":"Melanie D. Hicks","orcid":"0000-0002-7162-3008","position":0,"is_corresponding":true}],"reference_count":24,"raw_metadata":null,"created_at":"2026-07-18T23:52:27.434608Z","pmid":"34697855","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}