{"doi":"10.1002/hed.26245","title":"Prognostic significance of human papillomavirus and <scp>Epstein‐Bar</scp> virus in nasopharyngeal carcinoma","abstract":"BACKGROUND: The clinical significance of Epstein-Barr virus (EBV) and human papillomavirus (HPV) infection in nasopharyngeal carcinoma (NPC) is unclear. METHODS: Three hundred and forty three patients with NPC diagnosed between 1998 and 2017 and treated at our institution were included. Chi-square was used to identify characteristics associated with viral status. Kaplan-Meier methods were used to estimate overall survival (OS) and Cox proportional regression was used to identify prognostic factors. RESULTS: Patients with HPV-associated NPC were more likely to have a positive smoking history and to present at a higher T classification. At a median follow-up time of 59.9 months (range: 0.1-222.4 months), there were no differences in OS (P = .198), time to local failure (LF, P = .403), or time to distant metastasis (DM, P = .849) between the viral subgroups. Older age (hazard ratio [HR]: 2.242, 95% confidence interval [CI] 1.374-3.659, P = .001) and higher overall stage (HR: 2.047, 95% CI 1.235-3.391, P = .005) were prognostic for worse OS. CONCLUSION: In our population, viral status was not prognostic for OS, LF, or DM.","journal":"Head & Neck","year":2020,"id":77963,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":18,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9664,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":406170,"name":"Suchit H. Patel","orcid":"0000-0002-6478-5340","position":1,"is_corresponding":false},{"id":406171,"name":"Virginia Osborn","orcid":"0000-0001-8700-4861","position":2,"is_corresponding":false},{"id":255799,"name":"Sean M. McBride","orcid":"0000-0002-9676-1669","position":3,"is_corresponding":false},{"id":236122,"name":"Nadeem Riaz","orcid":"0000-0001-9873-5862","position":4,"is_corresponding":false},{"id":293157,"name":"Anna Lee","orcid":"0000-0002-9114-1815","position":5,"is_corresponding":false},{"id":255790,"name":"Nora Katabi","orcid":"0000-0003-2974-3046","position":6,"is_corresponding":false},{"id":255786,"name":"Eric J. Sherman","orcid":"0000-0002-4960-4783","position":7,"is_corresponding":false},{"id":255810,"name":"Nancy Y. Lee","orcid":"0000-0003-3044-9522","position":8,"is_corresponding":false},{"id":255798,"name":"C. Jillian Tsai","orcid":"0000-0003-0400-2655","position":9,"is_corresponding":false},{"id":406169,"name":"Nipun Verma","orcid":"0000-0002-9522-6699","position":0,"is_corresponding":true}],"reference_count":44,"raw_metadata":null,"created_at":"2026-07-18T21:49:40.769098Z","pmid":"32415906","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}