{"doi":"10.1002/hed.26244","title":"Significant association between host transcriptome‐derived <scp>HPV</scp> oncogene <scp>E6</scp>* influence score and carcinogenic pathways, tumor size, and survival in head and neck cancer","abstract":"BACKGROUND: Human papillomavirus (HPV) oncogenes E6, E7, and shorter isoforms of E6 (E6*) are known carcinogenic factors in head and neck squamous cell carcinoma (HNSCC). Little is known regarding E6* functions. METHODS: We analyzed RNA-seq data from 68 HNSCC HPV type 16-positive tumors to determine host genes and pathways associated with E6+E7 expression (E6E7) or the percent of full-length E6 (E6%FL). Influence scores of E6E7 and E6%FL were used to test for associations with clinical variables. RESULTS: For E6E7, we recapitulated all major known affected pathways and revealed additional pathways. E6%FL was found to affect mitochondrial processes, and E6%FL influence score was significantly associated with overall survival and tumor size. CONCLUSIONS: HPV E6E7 and E6* result in extensive, dose-dependent compensatory effects and dysregulation of key cancer pathways. The switch from E6 to E6* promotes oxidative phosphorylation, larger tumor size, and worse prognosis, potentially serving as a prognostic factor for HPV-positive HNSCC.","journal":"Head & Neck","year":2020,"id":85913,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":16,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9515,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":438394,"name":"Lada A. Koneva","orcid":"0000-0002-9529-4886","position":1,"is_corresponding":false},{"id":438395,"name":"Yidan Liu","orcid":"0000-0002-6148-266X","position":2,"is_corresponding":false},{"id":21276,"name":"Yanxiao Zhang","orcid":"0000-0001-9618-637X","position":3,"is_corresponding":false},{"id":404089,"name":"Anna E. Arthur","orcid":"0000-0002-5208-4336","position":4,"is_corresponding":false},{"id":365142,"name":"Katie R. Zarins","orcid":null,"position":5,"is_corresponding":false},{"id":13324,"name":"Thomas E. Carey","orcid":"0000-0002-5202-7518","position":6,"is_corresponding":false},{"id":426002,"name":"Douglas B. Chepeha","orcid":"0000-0001-9062-3719","position":7,"is_corresponding":false},{"id":70267,"name":"Gregory T. Wolf","orcid":"0000-0002-3219-9515","position":8,"is_corresponding":false},{"id":70266,"name":"Laura S. Rozek","orcid":"0000-0001-6731-7000","position":9,"is_corresponding":false},{"id":363234,"name":"Maureen A. Sartor","orcid":"0000-0001-6155-5702","position":10,"is_corresponding":false},{"id":418024,"name":"Tingting Qin","orcid":"0000-0003-3810-7578","position":0,"is_corresponding":true}],"reference_count":50,"raw_metadata":null,"created_at":"2026-07-18T21:58:16.217017Z","pmid":"32406560","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}