{"doi":"10.1002/hed.26104","title":"Prognostic value of epithelial‐mesenchymal transition‐inducing transcription factors in head and neck squamous cell carcinoma: A meta‐analysis","abstract":"<jats:title>Abstract</jats:title><jats:p>Epithelial‐mesenchymal transition (EMT) plays a critical role in cancer progression and is primarily regulated by several EMT‐inducing transcription factors (EMT‐TFs), including TWIST1, TWIST2, SNAI1, SNAI2, ZEB1, and ZEB2. However, the prognostic value of EMT‐TFs remains controversial in head and neck squamous cell carcinoma (HNSCC). Studies on the prognostic role of EMT‐TFs in HNSCC were searched for in the Web of Science, Science Direct, Proquest, EMBASE, PubMed, and Cochrane Library. Meta‐analysis was performed by using Revman 5.2 software. The pooled analysis showed that overexpression of EMT‐TFs indicated a poor overall survival (OS) (HR = 1.93, 95% CI = 1.67‐2.23) of HNSCC. Subgroup analysis for individual EMT‐TFs revealed that overexpression of TWIST1 (HR = 1.61, 95% CI = 1.29‐2.02), SNAI1 (HR = 2.17, 95% CI = 1.63‐2.88), SNAI2 (HR = 1.90, 95% CI = 1.38‐2.62), and ZEB1 (HR = 2.70, 95% CI = 1.61‐4.53) were significantly associated with poor OS of HNSCC. These findings support the hypothesis that overexpression of EMT‐TFs indicates a poor prognosis for HNSCC patients.</jats:p>","journal":"Head &amp; Neck","year":2020,"id":686018,"datarank":0.5456379239589579,"base_score":3.6375861597263857,"endowment":3.6375861597263857,"self_citation_contribution":0.5456379239589579,"citation_network_contribution":0.0,"self_endowment_contribution":0.5456379239589579,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":37,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":2,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1792320,"name":"Haichao Liu","orcid":null,"position":1,"is_corresponding":false},{"id":1407053,"name":"Ming Zhang","orcid":"0009-0003-0087-3493","position":2,"is_corresponding":false},{"id":1792321,"name":"Zhengxian Huang","orcid":null,"position":3,"is_corresponding":false},{"id":1213809,"name":"Han Zhou","orcid":"0000-0001-9608-6897","position":4,"is_corresponding":false},{"id":1077824,"name":"Yue Zhu","orcid":"0009-0002-2905-7855","position":5,"is_corresponding":false},{"id":1792322,"name":"Yifan Tao","orcid":null,"position":6,"is_corresponding":false},{"id":635040,"name":"Nan Xie","orcid":"0000-0002-1972-8187","position":7,"is_corresponding":false},{"id":635042,"name":"Xiqiang Liu","orcid":"0000-0003-1890-2857","position":8,"is_corresponding":false},{"id":635041,"name":"Jinsong Hou","orcid":"0000-0001-5330-9528","position":9,"is_corresponding":false},{"id":635046,"name":"Cheng Wang","orcid":"0000-0001-8155-5064","position":10,"is_corresponding":false},{"id":1792319,"name":"Yuehan Wan","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Prognostic value of epithelial‐mesenchymal transition‐inducing transcription factors in head and neck squamous cell carcinoma: A meta‐analysis","abstract":"<jats:title>Abstract</jats:title><jats:p>Epithelial‐mesenchymal transition (EMT) plays a critical role in cancer progression and is primarily regulated by several EMT‐inducing transcription factors (EMT‐TFs), including TWIST1, TWIST2, SNAI1, SNAI2, ZEB1, and ZEB2. However, the prognostic value of EMT‐TFs remains controversial in head and neck squamous cell carcinoma (HNSCC). Studies on the prognostic role of EMT‐TFs in HNSCC were searched for in the Web of Science, Science Direct, Proquest, EMBASE, PubMed, and Cochrane Library. Meta‐analysis was performed by using Revman 5.2 software. The pooled analysis showed that overexpression of EMT‐TFs indicated a poor overall survival (OS) (HR = 1.93, 95% CI = 1.67‐2.23) of HNSCC. Subgroup analysis for individual EMT‐TFs revealed that overexpression of TWIST1 (HR = 1.61, 95% CI = 1.29‐2.02), SNAI1 (HR = 2.17, 95% CI = 1.63‐2.88), SNAI2 (HR = 1.90, 95% CI = 1.38‐2.62), and ZEB1 (HR = 2.70, 95% CI = 1.61‐4.53) were significantly associated with poor OS of HNSCC. These findings support the hypothesis that overexpression of EMT‐TFs indicates a poor prognosis for HNSCC patients.</jats:p>","is_dataset_classified":null,"base_score":3.6375861597263857,"endowment":3.6375861597263857,"datacite_reuse_total":2,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"32048783","pmcid":null,"openalex_id":"https://openalex.org/W3005997435","authors":[],"funders":[{"funder_name":"Fundamental Research Funds for the Central Universities","grant_id":"11ykpy47","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"81572661","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"81202136","title":null},{"funder_name":"Natural Science Foundation of Guangdong Province","grant_id":"2017A030313515","title":null},{"funder_name":"Specialized Research Fund for the Doctoral Program of Higher Education of China","grant_id":"20120171120068","title":null}],"total_grants":5,"fwci":2.2028,"citation_percentile":0.90151737,"influential_citations":0,"citation_trend":[{"year":2020,"count":6},{"year":2021,"count":7},{"year":2022,"count":12},{"year":2023,"count":4},{"year":2024,"count":3},{"year":2025,"count":3},{"year":2026,"count":2}],"oa_status":"closed","license":"http://onlinelibrary.wiley.com/termsAndConditions#vor","oa_locations":[{"url":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fhed.26104","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/hed.26104","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/full-xml/10.1002/hed.26104","host_type":"publisher"},{"url":"https://doi.org/10.1002/hed.26104","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/32048783","host_type":"repository"}],"fields_of_study":["Cancer Cells and Metastasis","Metastasis and carcinoma case studies","Genetic factors in colorectal cancer","Biomarkers, Tumor","Epithelial-Mesenchymal Transition","Head and Neck Neoplasms","Humans","Prognosis","Squamous Cell Carcinoma of Head and Neck","Transcription Factors"],"mesh_terms":["Squamous Cell Carcinoma of Head and Neck","Head and Neck Neoplasms","Humans","Prognosis","Transcription Factors","Biomarkers, Tumor","Epithelial-Mesenchymal Transition"],"keywords":["SNAI1","Epithelial–mesenchymal transition","Head and neck squamous-cell carcinoma","Meta-analysis","Oncology","Internal medicine","Medicine","Cancer research","Head and neck cancer","Transcription factor","Biology","Cancer","Gene","Metastasis","Prognosis","Biomarkers","Hnscc","Emt-tfs"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"No poverty"}],"linked_datasets":[{"doi":"10.6084/m9.figshare.19254790.v1","title":"Additional file 1 of Construction and validation of a transcription factors-based prognostic signature for ovarian cancer","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.19254790","title":"Additional file 1 of Construction and validation of a transcription factors-based prognostic signature for ovarian cancer","publisher":"figshare","resource_type":"JournalArticle"}],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-18T18:21:34.618240Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}