{"doi":"10.1002/hed.26089","title":"MicroRNA‐based risk scoring system to identify early‐stage oral squamous cell carcinoma patients at high‐risk for cancer‐specific mortality","abstract":"BACKGROUND: For early-stage oral squamous cell carcinoma (OSCC), there is no existing risk-stratification modality beyond conventional TNM staging system to identify patients at high risk for cancer-specific mortality. METHODS: A total of 568 early-stage OSCC patients who had surgery only and also with available 5-year clinical outcomes data were identified. Signature microRNAs (miRNAs) were discovered using deep sequencing analysis and validated by qRT-PCR. The final 5-plex prognostic marker panel was utilized to generate a cancer-specific mortality risk score using the multivariate Cox regression analyses. The prognostic markers were validated in the internal and external validation cohorts. RESULTS: The risk score from the 5-plex marker panel consisting of miRNAs-127-3p, 4736, 655-3p, TNM stage and histologic grading stratified patients into four risk categories. Compared to the low-risk group, the high-risk group had 23-fold increased mortality risk (hazard ratio 23, 95% confidence interval 13-42), with a median time-to-recurrence of 6 months and time-to-death of 11 months (vs >60 months for each among low-risk patient; p < .001). CONCLUSION: The miRNA-based 5-plex marker panel driven mortality risk score formula provides clinically practical and reliable measures to assess the prognosis of patients assigned to an early-stage OSCC.","journal":"Head & Neck","year":2020,"id":59734,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":65,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.6273,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":314669,"name":"Shuang Wang","orcid":"0000-0002-8245-0464","position":1,"is_corresponding":false},{"id":314670,"name":"David I. Kutler","orcid":"0000-0003-2297-7077","position":2,"is_corresponding":false},{"id":268516,"name":"Richard D. Carvajal","orcid":"0000-0002-3796-1118","position":3,"is_corresponding":false},{"id":314671,"name":"Elizabeth Philipone","orcid":"0000-0001-8956-3923","position":4,"is_corresponding":false},{"id":314672,"name":"Tian Wang","orcid":"0000-0001-8111-2773","position":5,"is_corresponding":false},{"id":314673,"name":"Scott M. Peters","orcid":"0000-0002-2016-8375","position":6,"is_corresponding":false},{"id":316049,"name":"Dominic LaRoche","orcid":null,"position":7,"is_corresponding":false},{"id":33564,"name":"Brenda Y. Hernandez","orcid":"0000-0003-0132-4042","position":8,"is_corresponding":false},{"id":314674,"name":"Bradley D. McDowell","orcid":"0000-0001-8802-7686","position":9,"is_corresponding":false},{"id":314675,"name":"Claire Stewart","orcid":"0000-0002-7443-0906","position":10,"is_corresponding":false},{"id":245680,"name":"Fatemeh Momen‐Heravi","orcid":"0000-0003-4534-1450","position":11,"is_corresponding":false},{"id":314676,"name":"Regina M. Santella","orcid":"0000-0003-0823-6221","position":12,"is_corresponding":false},{"id":314668,"name":"Angela J. Yoon","orcid":"0000-0002-0529-7195","position":0,"is_corresponding":true}],"reference_count":50,"raw_metadata":null,"created_at":"2026-07-18T21:08:26.834549Z","pmid":"31981257","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}