{"doi":"10.1002/hbm.26757","title":"Functional dissociation of the language network and other cognition in early childhood","abstract":"Is language distinct from other cognition during development? Does neural machinery for language emerge from general-purpose neural mechanisms, becoming tuned for language after years of experience and maturation? Answering these questions will shed light on the origins of domain-specificity in the brain. We address these questions using precision fMRI, scanning young children (35 months to 9 years of age) on an auditory language localizer, spatial working memory localizer (engaging the domain-general multiple demand [MD] network), and a resting-state scan. We create subject-specific functional regions of interest for each network and examine their selectivity, specificity, and functional connectivity. We find young children show domain-specific, left-lateralized language activation, and that the language network is not responsive to domain-general cognitive load. Additionally, the cortically adjacent MD network is selective to cognitive load, but not to language. These networks show higher within versus between-network functional connectivity. This connectivity is stable across ages (examined cross-sectionally and longitudinally), whereas language responses increase with age and across time within subject, reflecting a domain-specific developmental change. Overall, we provide evidence for a double dissociation of the language and MD network throughout development, in both their function and connectivity. These findings suggest that domain-specificity, even for uniquely human cognition like language, develops early and distinctly from mechanisms that presumably support other human cognition.","journal":"Human Brain Mapping","year":2024,"id":423006,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":25,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9601,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":451634,"name":"Elana Schettini","orcid":"0000-0003-1099-0557","position":1,"is_corresponding":false},{"id":290702,"name":"Jin Li","orcid":"0000-0003-0890-4023","position":2,"is_corresponding":false},{"id":290705,"name":"Zeynep M. Saygin","orcid":"0000-0002-2191-0340","position":3,"is_corresponding":false},{"id":588750,"name":"Kelly J. Hiersche","orcid":"0000-0003-2609-4298","position":0,"is_corresponding":true}],"reference_count":57,"raw_metadata":null,"created_at":"2026-07-19T01:57:56.814994Z","pmid":"38888027","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}