{"doi":"10.1002/hbm.25364","title":"Cortical thickness across the lifespan: Data from 17,075 healthy individuals aged 3–90 years","abstract":"Delineating the association of age and cortical thickness in healthy individuals is critical given the association of cortical thickness with cognition and behavior. Previous research has shown that robust estimates of the association between age and brain morphometry require large-scale studies. In response, we used cross-sectional data from 17,075 individuals aged 3-90 years from the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) Consortium to infer age-related changes in cortical thickness. We used fractional polynomial (FP) regression to quantify the association between age and cortical thickness, and we computed normalized growth centiles using the parametric Lambda, Mu, and Sigma method. Interindividual variability was estimated using meta-analysis and one-way analysis of variance. For most regions, their highest cortical thickness value was observed in childhood. Age and cortical thickness showed a negative association; the slope was steeper up to the third decade of life and more gradual thereafter; notable exceptions to this general pattern were entorhinal, temporopolar, and anterior cingulate cortices. Interindividual variability was largest in temporal and frontal regions across the lifespan. Age and its FP combinations explained up to 59% variance in cortical thickness. These results may form the basis of further investigation on normative deviation in cortical thickness and its significance for behavioral and cognitive outcomes.","journal":"Human Brain Mapping","year":2021,"id":145845,"datarank":4.037803676485028,"base_score":5.707110264748875,"endowment":5.707110264748875,"self_citation_contribution":0.8560665397123315,"citation_network_contribution":3.181737136772697,"self_endowment_contribution":0.8560665397123315,"citer_contribution":3.181737136772697,"corpus_percentile":94.49214821691034,"corpus_rank":713,"citation_count":300,"citer_count":100,"citers_with_citation_signal":100,"citers_with_endowment":100,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":0.8064,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":4.1667,"fair_percentile":4.891470498318557,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":292047,"name":"Amirhossein Modabbernia","orcid":"0000-0003-1564-0441","position":1,"is_corresponding":false},{"id":316803,"name":"Steven Williams","orcid":"0000-0003-4299-1941","position":2,"is_corresponding":false},{"id":554061,"name":"Efstathios Papachristou","orcid":"0000-0001-5746-9561","position":3,"is_corresponding":false},{"id":246780,"name":"Gaëlle E. 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A reader reproducing your work against 'the current release' is reproducing it against a different dataset.","anchors":["yes","partial","no"],"verdict":"no","current":0.0,"evidence":null,"why":"No version token or date is given for the dataset.","gain":4.17,"priority":"useful","scored":true},{"key":"f_data_availability_statement","dimension":"F","label":"Data-availability statement","action":"Replace the statement with the repository template: name the repository and give the accession or DOI (Colavizza category 3). This is the only DAS class associated with a measured citation advantage; 'available on reasonable request' and 'within the article' are not.","anchors":["yes","partial","no"],"verdict":"partial","current":0.5,"evidence":"The ENIGMA Lifespan Working Group welcomes expression of interest from researchers in the field who wish to use the ENIGMA samples. Data sharing is possible subsequent to consent for the principal investigators of the contributing datasets. 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