{"doi":"10.1002/gps.70060","title":"Brain Signatures of Very Early Cognitive Decline in Asymptomatic Middle‐Aged Offspring of People With Alzheimer's Disease","abstract":"OBJECTIVE: To assess the relationship of subtle preclinical cognitive changes with white matter microstructure and cortical volume in middle-aged adults at high AD risk due to a parental history. METHODS: Participants (n = 278) were AD patients' offspring from the Israel Registry for Alzheimer's Prevention study. Cognitively unimpaired-decliners (CU-D) were based on a linear regression model. In a subsample with MRI (n = 220), we examined relationships of CU-D with white matter (WM) microstructure (fractional anisotropy [FA] and mean diffusivity [MD]) and cortical volume in brain regions commonly affected in AD. RESULTS: CU-D participants had lower FA in the superior longitudinal fasciculus (SLF) (p = < 0.001) and higher MD in the SLF (p = < 0.001), and cingulum adjacent to the corpus callosum (p = < 0.001) and genu (p = 0.006) compared to cognitively unimpaired-stable (CU-S) participants. The groups did not differ in cortical brain volumes. CONCLUSIONS: CU-D participants had poorer WM microstructure in brain tracts affected early in AD. Early interventions can target individuals that fit the CU-D criteria.","journal":"International Journal of Geriatric Psychiatry","year":2025,"id":551940,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8313,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":442214,"name":"Hung‐Mo Lin","orcid":"0000-0003-3176-6570","position":1,"is_corresponding":false},{"id":1429060,"name":"Yuxia Ouyang","orcid":"0000-0002-2671-6117","position":2,"is_corresponding":false},{"id":340322,"name":"Ramit Ravona‐Springer","orcid":"0000-0002-6440-3322","position":3,"is_corresponding":false},{"id":337515,"name":"Abigail Livny","orcid":"0000-0003-2216-7357","position":4,"is_corresponding":false},{"id":363834,"name":"Laili Soleimani","orcid":"0000-0002-1543-4616","position":5,"is_corresponding":false},{"id":291168,"name":"Barbara B. Bendlin","orcid":"0000-0002-0580-9875","position":6,"is_corresponding":false},{"id":1448192,"name":"Adar Matatov","orcid":null,"position":7,"is_corresponding":false},{"id":1448193,"name":"Tal Niv","orcid":null,"position":8,"is_corresponding":false},{"id":1448194,"name":"Tamar Shamir","orcid":null,"position":9,"is_corresponding":false},{"id":494551,"name":"Ithamar Ganmore","orcid":"0000-0003-3760-680X","position":10,"is_corresponding":false},{"id":340323,"name":"Anthony Heymann","orcid":"0000-0003-2353-9933","position":11,"is_corresponding":false},{"id":284623,"name":"Mary Sano","orcid":"0000-0001-8889-2944","position":12,"is_corresponding":false},{"id":1228414,"name":"Joseph Azuri","orcid":"0000-0003-1049-9848","position":13,"is_corresponding":false},{"id":340324,"name":"Michal Schnaider Beeri","orcid":"0000-0002-4254-9742","position":14,"is_corresponding":false},{"id":1447880,"name":"Nadia Ramsingh","orcid":"0000-0003-1068-4816","position":0,"is_corresponding":true}],"reference_count":67,"raw_metadata":null,"created_at":"2026-07-19T02:54:29.318076Z","pmid":"40050014","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}