{"doi":"10.1002/gps.5319","title":"The <scp>5‐HTTLPR</scp> long allele predicts two‐year longitudinal increases in cortisol and declines in verbal memory in older adults","abstract":"OBJECTIVES: The short form or s-allele variant of the serotonin transporter polymorphism (5-HTTLPR), as compared with the long-form or l-allele variant, has been associated with the presence of cognitive dysfunction, and particularly memory impairment in older adults. This body of cross-sectional work has culminated in the hypothesis that presence of the s-allele predicts greater memory decline in older adults. Yet, to date, there are no longitudinal studies that have investigated this issue. METHODS/DESIGN: Here, we examine 109 community-dwelling older adults (mean and SD of age = 70.7 ± 8.7 years) who underwent blood draw for genotyping, cognitive, and psychological testing at baseline, 12-, and 24-monthfollow-ups. RESULTS: Multilevel modeling found that s-allele carriers (ss or ls) performed worse than ll homozygotes at baseline on delayed verbal recall. Yet, s-allele carriers' memory performance was stable over the two-yearfollow-up period, while l-allele homozygotes experienced significant memory decline. l-allele homozygote status was associated with both increased cortisol and decreased memory over time, resulting in attenuated verbal memory performance differences compared to s-allele carriers with age. CONCLUSIONS: Overall, our findings do not support the hypothesis that presence of the 5-HTTLPRs-allele is a marker for memory decline in older adults. J Am Geriatr Soc 68:-, 2020.","journal":"International Journal of Geriatric Psychiatry","year":2020,"id":84046,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":10,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9512,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":308792,"name":"Joshua T. Jordan","orcid":"0000-0001-7007-8098","position":1,"is_corresponding":false},{"id":5627,"name":"Sophia Miryam Schüssler-Fiorenza Rose","orcid":"0000-0002-6311-6671","position":2,"is_corresponding":false},{"id":431856,"name":"Logan Schneider","orcid":"0000-0001-8729-5224","position":3,"is_corresponding":false},{"id":431857,"name":"Makoto Kawai","orcid":"0000-0001-9176-4388","position":4,"is_corresponding":false},{"id":431858,"name":"Christine E. Gould","orcid":"0000-0001-8901-2363","position":5,"is_corresponding":false},{"id":431859,"name":"Lauren Anker","orcid":"0000-0002-6153-217X","position":6,"is_corresponding":false},{"id":431860,"name":"Christina F. Chick","orcid":"0000-0002-6517-6213","position":7,"is_corresponding":false},{"id":431861,"name":"Sherry A. Beaudreau","orcid":"0000-0002-9853-9332","position":8,"is_corresponding":false},{"id":21406,"name":"Joachim Hallmayer","orcid":"0000-0002-8520-4939","position":9,"is_corresponding":false},{"id":431862,"name":"Ruth O’Hara","orcid":"0000-0001-6583-4995","position":10,"is_corresponding":false},{"id":431855,"name":"Rayna B. Hirst","orcid":"0000-0001-5586-9641","position":0,"is_corresponding":true}],"reference_count":27,"raw_metadata":null,"created_at":"2026-07-18T21:54:50.827092Z","pmid":"32400901","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}