{"doi":"10.1002/glia.24092","title":"Glial <scp>ER</scp> and <scp>GAP</scp> junction mediated Ca<sup>2+</sup> waves are crucial to maintain normal brain excitability","abstract":"Abstract Astrocytes play key roles in regulating multiple aspects of neuronal function from invertebrates to humans and display Ca 2+ fluctuations that are heterogeneously distributed throughout different cellular microdomains. Changes in Ca 2+ dynamics represent a key mechanism for how astrocytes modulate neuronal activity. An unresolved issue is the origin and contribution of specific glial Ca 2+ signaling components at distinct astrocytic domains to neuronal physiology and brain function. The Drosophila model system offers a simple nervous system that is highly amenable to cell‐specific genetic manipulations to characterize the role of glial Ca 2+ signaling. Here we identify a role for ER store‐operated Ca 2+ entry (SOCE) pathway in perineurial glia (PG), a glial population that contributes to the Drosophila blood–brain barrier. We show that PG cells display diverse Ca 2+ activity that varies based on their locale within the brain. Ca 2+ signaling in PG cells does not require extracellular Ca 2+ and is blocked by inhibition of SOCE, Ryanodine receptors, or gap junctions. Disruption of these components triggers stimuli‐induced seizure‐like episodes. These findings indicate that Ca 2+ release from internal stores and its propagation between neighboring glial cells via gap junctions are essential for maintaining normal nervous system function.","journal":"Glia","year":2021,"id":165915,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":35,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9568,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":571982,"name":"Lauren C. Clamon","orcid":null,"position":1,"is_corresponding":false},{"id":571315,"name":"Julia E. Manoim","orcid":"0000-0002-1581-9639","position":2,"is_corresponding":false},{"id":305495,"name":"Kiel G. Ormerod","orcid":"0000-0002-9739-8777","position":3,"is_corresponding":false},{"id":571316,"name":"Moshe Parnas","orcid":"0000-0001-9726-1511","position":4,"is_corresponding":false},{"id":305497,"name":"J. Troy Littleton","orcid":"0000-0001-5576-2887","position":5,"is_corresponding":false},{"id":571314,"name":"Shirley Weiss","orcid":"0000-0002-1006-349X","position":0,"is_corresponding":true}],"reference_count":76,"raw_metadata":null,"created_at":"2026-07-18T23:45:45.220559Z","pmid":"34528727","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}