{"doi":"10.1002/gene.10089","title":"Induced DNA recombination by Cre recombinase protein transduction","abstract":"<jats:title>Abstract</jats:title><jats:p>Summary: Cre is a DNA recombinase that recognizes 34 base‐pair <jats:italic>loxP</jats:italic> sites of recombination. We have developed a cell‐permeable Cre recombinase, TATCre, that is capable of mediating deletion of <jats:italic>loxP</jats:italic>‐flanked targets by simply adding TATCre to cell cultures. Thus, TATCre allows efficient induced DNA recombination without the use of a Cre recombinase transgene or any other genetic material and should prove useful for the genetic manipulation of a wide variety of cell types that have been engineered to possess <jats:italic>loxP</jats:italic> sites. genesis 33:48–54, 2002. © 2002 Wiley‐Liss, Inc.</jats:p>","journal":"genesis","year":2002,"id":593741,"datarank":0.6010999777848708,"base_score":4.007333185232471,"endowment":4.007333185232471,"self_citation_contribution":0.6010999777848708,"citation_network_contribution":0.0,"self_endowment_contribution":0.6010999777848708,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":54,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1519732,"name":"Kahoko Hashimoto","orcid":null,"position":1,"is_corresponding":false},{"id":417574,"name":"Pandelakis A. 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Thus, TATCre allows efficient induced DNA recombination without the use of a Cre recombinase transgene or any other genetic material and should prove useful for the genetic manipulation of a wide variety of cell types that have been engineered to possess <jats:italic>loxP</jats:italic> sites. genesis 33:48–54, 2002. © 2002 Wiley‐Liss, Inc.</jats:p>","is_dataset_classified":null,"base_score":4.007333185232471,"endowment":4.007333185232471,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"12001069","pmcid":null,"openalex_id":"https://openalex.org/W2141803553","authors":[],"funders":[{"funder_name":"NCRR NIH HHS","grant_id":"R24 RR017280","title":null}],"total_grants":1,"fwci":2.0613,"citation_percentile":0.87010628,"influential_citations":5,"citation_trend":[{"year":2012,"count":3},{"year":2013,"count":1},{"year":2014,"count":3},{"year":2015,"count":4},{"year":2016,"count":1},{"year":2017,"count":1},{"year":2018,"count":1},{"year":2025,"count":1},{"year":2026,"count":1}],"oa_status":"closed","license":"http://onlinelibrary.wiley.com/termsAndConditions#vor","oa_locations":[{"url":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fgene.10089","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/gene.10089","host_type":"publisher"},{"url":"https://doi.org/10.1002/gene.10089","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/12001069","host_type":"repository"}],"fields_of_study":["RNA Interference and Gene Delivery","CRISPR and Genetic Engineering","Advanced biosensing and bioanalysis techniques","Biology","Medicine","Animals","Fibroblasts","Integrases","Mice","Recombinant Fusion Proteins","Recombination, Genetic","Viral Proteins"],"mesh_terms":["Animals","Fibroblasts","Recombinant Fusion Proteins","Recombination, Genetic","Viral Proteins","Integrases","Mice"],"keywords":["Cre recombinase","Recombinase","Cre-Lox recombination","Site-specific recombination","Transduction (biophysics)","DNA","Biology","Genetics","Transgene","Recombination","Genetic recombination","FLP-FRT recombination","Cell biology","Molecular biology","Genetically modified mouse","Gene","Biophysics"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-27T12:06:18.604740Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}