{"doi":"10.1002/eji.70067","title":"Antigen‐Specific Tolerance: Clinical and Preclinical Approaches in Autoimmunity","abstract":"Autoimmune diseases arise from a breakdown in immune tolerance. This leads to self-reactive immune responses and chronic inflammation. Induction of antigen-specific tolerance offers a targeted approach that restores immune balance without global immunosuppression. We discuss current approaches to therapies that seek to induce tolerance. These include peptide-, immunoglobulin-, carrier-, and cell-based approaches. We review clinical trials and preclinical studies that explore novel strategies for the induction of durable (antigen-specific) tolerance as possible interventions in autoimmune disease.","journal":"European Journal of Immunology","year":2025,"id":527111,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.956,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1403771,"name":"Stephanie D. Scharmann","orcid":null,"position":1,"is_corresponding":false},{"id":89095,"name":"Novalia Pishesha","orcid":"0000-0002-8124-1265","position":2,"is_corresponding":false},{"id":1403770,"name":"Priscilla P. M. Faas","orcid":null,"position":0,"is_corresponding":true}],"reference_count":49,"raw_metadata":null,"created_at":"2026-07-19T02:50:34.851930Z","pmid":"41054017","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}