{"doi":"10.1002/eji.202451076","title":"Nurturing the phenotype: Environmental signals and transcriptional regulation of intestinal γδ T cells","abstract":"<jats:title>Abstract</jats:title>\n                  <jats:p>The intestinal epithelium harbours a unique lymphocyte population, the intraepithelial lymphocytes (IELs). A large fraction of IELs is represented by γδ T cells. Their role in epithelial homeostasis and immune response is well documented, but a conclusive view of their developmental pathway is still missing. In this review, we discuss the existing literature as well as recent advances regarding the tissue adaptation of γδ IELs, both for the characteristic cytotoxic subset and the newly described noncytotoxic subset. We particularly highlight the environmental cues and the transcriptional regulation that equip γδ T cells with their IEL phenotype.</jats:p>","journal":"European Journal of Immunology","year":2024,"id":614059,"datarank":0.10397207708399181,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"self_citation_contribution":0.10397207708399181,"citation_network_contribution":0.0,"self_endowment_contribution":0.10397207708399181,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1582244,"name":"Thomas H. Winkler","orcid":null,"position":1,"is_corresponding":false},{"id":1582243,"name":"Lisa Vogg*","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Nurturing the phenotype: Environmental signals and transcriptional regulation of intestinal γδ T cells","abstract":"<jats:title>Abstract</jats:title>\n                  <jats:p>The intestinal epithelium harbours a unique lymphocyte population, the intraepithelial lymphocytes (IELs). A large fraction of IELs is represented by γδ T cells. Their role in epithelial homeostasis and immune response is well documented, but a conclusive view of their developmental pathway is still missing. In this review, we discuss the existing literature as well as recent advances regarding the tissue adaptation of γδ IELs, both for the characteristic cytotoxic subset and the newly described noncytotoxic subset. We particularly highlight the environmental cues and the transcriptional regulation that equip γδ T cells with their IEL phenotype.</jats:p>","is_dataset_classified":null,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"39136644","pmcid":null,"openalex_id":"https://openalex.org/W4401541565","authors":[],"funders":[{"funder_name":"Deutsche Forschungsgemeinschaft","grant_id":"FOR2799","title":null},{"funder_name":"Deutsche Forschungsgemeinschaft","grant_id":"395236335","title":null},{"funder_name":"Deutsche Forschungsgemeinschaft","grant_id":"unidentified","title":"unidentified"}],"total_grants":3,"fwci":0.1607,"citation_percentile":0.46431038,"influential_citations":0,"citation_trend":[{"year":2025,"count":1}],"oa_status":"hybrid","license":"cc-by-nc-nd","oa_locations":[{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/eji.202451076","host_type":"journal"},{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/eji.202451076","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/eji.202451076","host_type":"publisher"},{"url":"https://doi.org/10.1002/eji.202451076","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/39136644","host_type":"repository"},{"url":"https://open.fau.de/handle/openfau/34518","host_type":""}],"fields_of_study":["Immune Cell Function and Interaction","T-cell and B-cell Immunology","IL-33, ST2, and ILC Pathways","0301 basic medicine","0303 health sciences","03 medical and health sciences","Humans","Animals","Receptors, Antigen, T-Cell, gamma-delta","Intraepithelial Lymphocytes","Intestinal Mucosa","Phenotype","Gene Expression Regulation","Homeostasis","T-Lymphocyte Subsets"],"mesh_terms":["Intraepithelial Lymphocytes","Animals","Gene Expression Regulation","Homeostasis","Humans","Intestinal Mucosa","Phenotype","T-Lymphocyte Subsets","Receptors, Antigen, T-Cell, gamma-delta"],"keywords":["Intraepithelial lymphocyte","Biology","Phenotype","Cytotoxic T cell","Immune system","Cell biology","Homeostasis","Immunology","Intestinal epithelium","Population","Adaptation (eye)","Epithelium","Genetics","Gene","In vitro","Neuroscience","Intestine","Transcriptional regulation","Iel","Γδ T Cells","Tissue Adaptation","Receptors, Antigen, T-Cell, gamma-delta","Gene Expression Regulation","T-Lymphocyte Subsets","Humans","Animals","Intestinal Mucosa","Intraepithelial Lymphocytes"],"sdg_mappings":[{"sdg_number":3,"sdg_label":"3. Good health"},{"sdg_number":0,"sdg_label":"Life below water"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-02T10:27:46.862958Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}