{"doi":"10.1002/eji.202350721","title":"Temporal associations of plasma levels of the secreted phospholipase A <sub>2</sub> family and mortality in severe COVID‐19","abstract":"Abstract Previous research suggests that group IIA‐secreted phospholipase A 2 (sPLA 2 ‐IIA) plays a role in and predicts lethal COVID‐19 disease. The current study reanalyzed a longitudinal proteomic data set to determine the temporal relationship between levels of several members of a family of sPLA 2 isoforms and the severity of COVID‐19 in 214 ICU patients. The levels of six secreted PLA 2 isoforms, sPLA 2 ‐IIA, sPLA 2 ‐V, sPLA 2 ‐X, sPLA 2 ‐IB, sPLA 2 ‐IIC, and sPLA 2 ‐XVI, increased over the first 7 ICU days in those who succumbed to the disease but attenuated over the same time period in survivors. In contrast, a reversed pattern in sPLA 2 ‐IID and sPLA 2 ‐XIIB levels over 7 days suggests a protective role of these two isoforms. Furthermore, decision tree models demonstrated that sPLA 2 ‐IIA outperformed top‐ranked cytokines and chemokines as a predictor of patient outcome. Taken together, proteomic analysis revealed temporal sPLA 2 patterns that reflect the critical roles of sPLA 2 isoforms in severe COVID‐19 disease.","journal":"European Journal of Immunology","year":2024,"id":470884,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9308,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1305533,"name":"Aki Hara","orcid":null,"position":1,"is_corresponding":false},{"id":1305200,"name":"Shudong Sun","orcid":"0009-0007-1953-1281","position":2,"is_corresponding":false},{"id":263814,"name":"Brian Hallmark","orcid":"0000-0002-6790-0471","position":3,"is_corresponding":false},{"id":367195,"name":"Justin M. Snider","orcid":"0000-0003-4102-698X","position":4,"is_corresponding":false},{"id":324993,"name":"Michael C. Seeds","orcid":null,"position":5,"is_corresponding":false},{"id":500735,"name":"Joseph C. Watkins","orcid":"0000-0001-6464-1972","position":6,"is_corresponding":false},{"id":483155,"name":"Charles E. McCall","orcid":"0000-0002-9082-469X","position":7,"is_corresponding":false},{"id":449341,"name":"Hao Helen Zhang","orcid":"0000-0001-8873-3329","position":8,"is_corresponding":false},{"id":535483,"name":"Guang Yao","orcid":"0000-0003-3238-8479","position":9,"is_corresponding":false},{"id":263815,"name":"Floyd H. Chilton","orcid":"0000-0002-3686-0198","position":10,"is_corresponding":false},{"id":1305199,"name":"Eric Lu","orcid":"0009-0002-1979-0033","position":0,"is_corresponding":true}],"reference_count":52,"raw_metadata":null,"created_at":"2026-07-19T02:05:40.740958Z","pmid":"38651231","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}