{"doi":"10.1002/eji.201948391","title":"Antibody, but not B‐cell–dependent antigen presentation, plays an essential role in preventing <i>Chlamydia</i> systemic dissemination in mice","abstract":"Abstract The obligate intracellular bacterium Chlamydia trachomatis causes the most prevalent bacterial sexually transmitted infection worldwide. CD4 T cells play a central role in the protective immunity against Chlamydia female reproductive tract (FRT) infection, while B cells are thought to be dispensable for resolution of primary Chlamydia infection in mouse models. We recently reported an unexpected requirement of B cells in local Chlamydia ‐specific CD4 T‐cell priming and bacterial containment within the FRT. Here, we sought to tackle the precise effector function of B cells during Chlamydia primary infection. Using mixed bone marrow chimeras that lack B‐cell–dependent Ag presentation ( ) or devoid of circulating antibodies (AID −/− × μS −/− ), we show that Chlamydia ‐specific CD4 T‐cell expansion does not rely on Ag presentation by B cells. Importantly, we demonstrate that antibody, but not B‐cell–dependent Ag presentation, is required for preventing systemic bacterial dissemination following Chlamydia FRT infection.","journal":"European Journal of Immunology","year":2020,"id":86755,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":12,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9548,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":400861,"name":"Miguel A. B. Mercado","orcid":null,"position":1,"is_corresponding":false},{"id":366401,"name":"Stephen J. McSorley","orcid":"0000-0002-6363-3222","position":2,"is_corresponding":false},{"id":399487,"name":"Lin‐Xi Li","orcid":"0000-0002-5526-8966","position":3,"is_corresponding":false},{"id":400862,"name":"Priyangi A. Malaviarachchi","orcid":null,"position":0,"is_corresponding":true}],"reference_count":60,"raw_metadata":null,"created_at":"2026-07-18T21:59:03.706190Z","pmid":"32026472","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}