{"doi":"10.1002/eji.1830220305","title":"V<sub>β</sub> repertoire in rats and implications for endogenous superantigens","abstract":"<jats:title>Abstract</jats:title><jats:p>Endogenous superantigens of mice, encoded by mammary tumor virus proviral integrants, induce intrathymic deletion of entire T cell populations that express specific V<jats:sub>β</jats:sub> gene products, a phenomenon proposed to be important in self‐tolerance and prevention of toxic responses to exogenous microbial superantigens. Evidence for the presence of V<jats:sub>β</jats:sub> selecting/deleting endogenous superantigens in other species is lacking. We report here that rats do not exhibit endogenous superantigen‐induced V<jats:sub>β</jats:sub> clonal deletions despite their strong response to bacterial superantigens. These findings indicate that endogenous superantigens are not obligatory in V<jats:sub>β</jats:sub> repertoire shaping.</jats:p>","journal":"European Journal of Immunology","year":1992,"id":644971,"datarank":0.49983067652628066,"base_score":3.332204510175204,"endowment":3.332204510175204,"self_citation_contribution":0.49983067652628066,"citation_network_contribution":0.0,"self_endowment_contribution":0.49983067652628066,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":27,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":135554,"name":"Dwight H. Kono","orcid":null,"position":1,"is_corresponding":false},{"id":1679117,"name":"Michael E. Kammuller","orcid":null,"position":2,"is_corresponding":false},{"id":1679119,"name":"Robert S. Balderas","orcid":null,"position":3,"is_corresponding":false},{"id":882768,"name":"Argyrios N. Theofilopoulos","orcid":null,"position":4,"is_corresponding":false},{"id":1679115,"name":"Lawrence R. Smith","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"V<sub>β</sub> repertoire in rats and implications for endogenous superantigens","abstract":"<jats:title>Abstract</jats:title><jats:p>Endogenous superantigens of mice, encoded by mammary tumor virus proviral integrants, induce intrathymic deletion of entire T cell populations that express specific V<jats:sub>β</jats:sub> gene products, a phenomenon proposed to be important in self‐tolerance and prevention of toxic responses to exogenous microbial superantigens. Evidence for the presence of V<jats:sub>β</jats:sub> selecting/deleting endogenous superantigens in other species is lacking. We report here that rats do not exhibit endogenous superantigen‐induced V<jats:sub>β</jats:sub> clonal deletions despite their strong response to bacterial superantigens. These findings indicate that endogenous superantigens are not obligatory in V<jats:sub>β</jats:sub> repertoire shaping.</jats:p>","is_dataset_classified":null,"base_score":3.332204510175204,"endowment":3.332204510175204,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"1312471","pmcid":null,"openalex_id":"https://openalex.org/W2031687972","authors":[],"funders":[],"total_grants":0,"fwci":1.2153,"citation_percentile":0.79113614,"influential_citations":0,"citation_trend":[],"oa_status":"closed","license":"http://onlinelibrary.wiley.com/termsAndConditions#vor","oa_locations":[{"url":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Feji.1830220305","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/eji.1830220305","host_type":"publisher"},{"url":"https://doi.org/10.1002/eji.1830220305","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/1312471","host_type":"repository"}],"fields_of_study":["Immune Response and Inflammation","Immune Cell Function and Interaction","Immunotherapy and Immune Responses"],"mesh_terms":["Animals","Antigens, Viral","Bacterial Toxins","Mammary Tumor Virus, Mouse","Rats, Inbred Strains","Species Specificity","Transcription, Genetic","Receptors, Antigen, T-Cell, alpha-beta","Mice","Rats"],"keywords":["Superantigen","Biology","Repertoire","Endogeny","Immunology","Computational biology","Cell biology","Evolutionary biology","Genetics","T cell","Immune system","Endocrinology"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-09T02:32:01.820794Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}