{"doi":"10.1002/ejhf.2797","title":"Transcatheter Mitral Valve Replacement or Repair for Secondary Mitral Regurgitation: A Propensity Score-Matched Analysis","abstract":"<jats:title>ABSTRACT</jats:title>\n                  <jats:sec>\n                    <jats:title>Aims</jats:title>\n                    <jats:p>This study aimed to compare outcomes after transcatheter mitral valve replacement (TMVR) and mitral valve transcatheter edge-to-edge repair (M-TEER) for the treatment of secondary mitral regurgitation (SMR).</jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results</jats:title>\n                    <jats:p>The CHOICE-MI registry included 262 patients with SMR treated with TMVR between 2014 and 2022. The EuroSMR registry included 1065 patients with SMR treated with M-TEER between 2014 and 2019. Propensity score (PS) matching was performed for 12 demographic, clinical and echocardiographic parameters. Echocardiographic, functional and clinical outcomes out to 1 year were compared in the matched cohorts. After PS matching, 235 TMVR patients (75.5 years [70.0, 80.0], 60.2% male, EuroSCORE II 6.3% [interquartile range 3.8, 12.4]) were compared to 411 M-TEER patients (76.7 years [70.1, 80.5], 59.0% male, EuroSCORE II 6.7% [3.9, 12.4]). All-cause mortality was 6.8% after TMVR and 3.8% after M-TEER at 30 days (p = 0.11), and 25.8% after TMVR and 18.9% after M-TEER at 1 year (p = 0.056). No differences in mortality after 1 year were found between both groups in a 30-day landmark analysis (TMVR: 20.4%, M-TEER: 15.8%, p = 0.21). Compared to M-TEER, TMVR resulted in more effective mitral regurgitation (MR) reduction (residual MR ≤1+ at discharge for TMVR vs. M-TEER: 95.8% vs. 68.8%, p &amp;lt; 0.001), and superior symptomatic improvement (New York Heart Association class ≤II at 1 year: 77.8% vs. 64.3%, p = 0.015).</jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion</jats:title>\n                    <jats:p>In this PS-matched comparison between TMVR and M-TEER in patients with severe SMR, TMVR was associated with superior reduction of MR and superior symptomatic improvement. While post-procedural mortality tended to be higher after TMVR, no significant differences in mortality were found beyond 30 days.</jats:p>\n                  </jats:sec>","journal":"European Journal of Heart Failure","year":2023,"id":639053,"datarank":0.5289540786924243,"base_score":3.5263605246161616,"endowment":3.5263605246161616,"self_citation_contribution":0.5289540786924243,"citation_network_contribution":0.0,"self_endowment_contribution":0.5289540786924243,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":33,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1660128,"name":"Daniel Kalbacher","orcid":null,"position":1,"is_corresponding":false},{"id":1483861,"name":"Walid Ben Ali","orcid":"0000-0003-0964-6433","position":2,"is_corresponding":false},{"id":1201901,"name":"Jessica Weimann","orcid":null,"position":3,"is_corresponding":false},{"id":902152,"name":"Matti Adam","orcid":"0000-0002-6990-8135","position":4,"is_corresponding":false},{"id":1108973,"name":"Alison Duncan","orcid":"0000-0002-7809-1454","position":5,"is_corresponding":false},{"id":1081708,"name":"John G. Webb","orcid":"0000-0001-7903-2870","position":6,"is_corresponding":false},{"id":2652,"name":"Stephan Windecker","orcid":"0000-0003-2653-6762","position":7,"is_corresponding":false},{"id":1587640,"name":"Mathias Orban","orcid":"0000-0001-7846-8808","position":8,"is_corresponding":false},{"id":1660133,"name":"Cristina Giannini","orcid":"0000-0002-5472-6881","position":9,"is_corresponding":false},{"id":1044000,"name":"Augustin Coisne","orcid":"0000-0002-1662-7874","position":10,"is_corresponding":false},{"id":1421426,"name":"Nicole Karam","orcid":"0000-0002-3861-6914","position":11,"is_corresponding":false},{"id":1308859,"name":"Andrea Scotti","orcid":"0000-0003-4731-4384","position":12,"is_corresponding":false},{"id":619389,"name":"Lars Sondergaard","orcid":null,"position":13,"is_corresponding":false},{"id":49609,"name":"Marianna Adamo","orcid":"0000-0002-3855-1815","position":14,"is_corresponding":false},{"id":1608307,"name":"David W.M. Muller","orcid":null,"position":15,"is_corresponding":false},{"id":1660134,"name":"Christian Butter","orcid":null,"position":16,"is_corresponding":false},{"id":308900,"name":"Paolo Denti","orcid":"0000-0001-7494-079X","position":17,"is_corresponding":false},{"id":1660135,"name":"Bruno Melica","orcid":null,"position":18,"is_corresponding":false},{"id":1660136,"name":"Damiano Regazzoli","orcid":null,"position":19,"is_corresponding":false},{"id":1660137,"name":"Andrea Garatti","orcid":null,"position":20,"is_corresponding":false},{"id":894094,"name":"Tobias Schmidt","orcid":"0000-0001-7230-1214","position":21,"is_corresponding":false},{"id":1660138,"name":"Martin Andreas","orcid":null,"position":22,"is_corresponding":false},{"id":1425665,"name":"Gry Dahle","orcid":"0000-0002-6381-6766","position":23,"is_corresponding":false},{"id":1610785,"name":"Maurizio Taramasso","orcid":null,"position":24,"is_corresponding":false},{"id":968893,"name":"Georg Nickenig","orcid":null,"position":25,"is_corresponding":false},{"id":1660139,"name":"Nicolas Dumonteil","orcid":null,"position":26,"is_corresponding":false},{"id":55581,"name":"Thomas Walther","orcid":"0000-0001-8114-1785","position":27,"is_corresponding":false},{"id":1660140,"name":"Michele Flagiello","orcid":null,"position":28,"is_corresponding":false},{"id":1660141,"name":"Joerg Kempfert","orcid":null,"position":29,"is_corresponding":false},{"id":1660142,"name":"Neil Fam","orcid":null,"position":30,"is_corresponding":false},{"id":1660143,"name":"Hendrik Ruge","orcid":null,"position":31,"is_corresponding":false},{"id":1660144,"name":"Tanja K. Rudolph","orcid":null,"position":32,"is_corresponding":false},{"id":945628,"name":"Moritz C. Wyler von Ballmoos","orcid":null,"position":33,"is_corresponding":false},{"id":49608,"name":"Marco Metra","orcid":"0000-0001-6691-8568","position":34,"is_corresponding":false},{"id":541164,"name":"Simon Redwood","orcid":"0000-0002-1937-063X","position":35,"is_corresponding":false},{"id":51562,"name":"Juan F. Granada","orcid":"0000-0003-2399-8320","position":36,"is_corresponding":false},{"id":246542,"name":"Gilbert H.L. Tang","orcid":"0000-0001-7219-990X","position":37,"is_corresponding":false},{"id":457662,"name":"Azeem Latib","orcid":"0000-0001-9035-343X","position":38,"is_corresponding":false},{"id":767235,"name":"Philipp Lurz","orcid":"0000-0002-5993-4487","position":39,"is_corresponding":false},{"id":1659738,"name":"Ralph Stephan von Bardeleben","orcid":"0000-0002-1356-0037","position":40,"is_corresponding":false},{"id":1660145,"name":"Thomas Modine","orcid":null,"position":41,"is_corresponding":false},{"id":636863,"name":"Jörg Hausleiter","orcid":"0000-0003-2909-7961","position":42,"is_corresponding":false},{"id":906896,"name":"Lenard Conradi","orcid":"0000-0003-2237-9050","position":43,"is_corresponding":false},{"id":1024112,"name":"Sebastian Ludwig","orcid":"0000-0002-5752-4951","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Transcatheter mitral valve replacement or repair for secondary mitral regurgitation: a propensity score-matched analysis.","abstract":"<h4>Aims</h4>This study aimed to compare outcomes after transcatheter mitral valve replacement (TMVR) and mitral valve transcatheter edge-to-edge repair (M-TEER) for the treatment of secondary mitral regurgitation (SMR).<h4>Methods and results</h4>The CHOICE-MI registry included 262 patients with SMR treated with TMVR between 2014 and 2022. The EuroSMR registry included 1065 patients with SMR treated with M-TEER between 2014 and 2019. Propensity score (PS) matching was performed for 12 demographic, clinical and echocardiographic parameters. Echocardiographic, functional and clinical outcomes out to 1 year were compared in the matched cohorts. After PS matching, 235 TMVR patients (75.5 years [70.0, 80.0], 60.2% male, EuroSCORE II 6.3% [interquartile range 3.8, 12.4]) were compared to 411 M-TEER patients (76.7 years [70.1, 80.5], 59.0% male, EuroSCORE II 6.7% [3.9, 12.4]). All-cause mortality was 6.8% after TMVR and 3.8% after M-TEER at 30 days (p = 0.11), and 25.8% after TMVR and 18.9% after M-TEER at 1 year (p = 0.056). No differences in mortality after 1 year were found between both groups in a 30-day landmark analysis (TMVR: 20.4%, M-TEER: 15.8%, p = 0.21). Compared to M-TEER, TMVR resulted in more effective mitral regurgitation (MR) reduction (residual MR ≤1+ at discharge for TMVR vs. M-TEER: 95.8% vs. 68.8%, p < 0.001), and superior symptomatic improvement (New York Heart Association class ≤II at 1 year: 77.8% vs. 64.3%, p = 0.015).<h4>Conclusion</h4>In this PS-matched comparison between TMVR and M-TEER in patients with severe SMR, TMVR was associated with superior reduction of MR and superior symptomatic improvement. While post-procedural mortality tended to be higher after TMVR, no significant differences in mortality were found beyond 30 days.","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"36883620","pmcid":null,"openalex_id":null,"authors":[],"funders":[{"funder_name":"Deutsche Herzstiftung","grant_id":"S/04/21","title":null}],"total_grants":1,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"hybrid","license":"cc-by-nc","oa_locations":[{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ejhf.2797","host_type":"publisher"},{"url":"https://curis.ku.dk/ws/files/367123099/European_J_of_Heart_Fail_2023_Ludwig.pdf","host_type":"repository"},{"url":"https://boris.unibe.ch/190857/","host_type":"repository"},{"url":"https://doi.org/10.48350/190857","host_type":"repository"}],"fields_of_study":[],"mesh_terms":["Mitral Valve","Humans","Mitral Valve Insufficiency","Treatment Outcome","Heart Valve Prosthesis Implantation","Female","Male","Heart Failure","Propensity Score","Cardiac Catheterization"],"keywords":["Functional Mitral Regurgitation","Secondary Mitral Regurgitation","Transcatheter Mitral Valve Replacement","Transcatheter Edge-to-edge Repair"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-06T22:22:25.377576Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}