{"doi":"10.1002/ejhf.2277","title":"Baseline Characteristics of Patients in the PARALLAX Trial: Insights Into Quality of Life and Exercise Capacity in Heart Failure with Preserved Ejection Fraction","abstract":"AIMS: We sought to describe the baseline characteristics of PARALLAX [a randomized controlled trial of sacubitril/valsartan vs. individualized medical therapy in heart failure (HF) with mildly reduced and preserved ejection fraction (HFpEF)]; compare PARALLAX to recent HFpEF trials; and examine the clinical characteristics associated with quality of life (QOL) and 6-min walk test distance (6MWD). METHODS AND RESULTS: A total of 2566 patients with HF and left ventricular ejection fraction (LVEF) >40% were randomized, of whom 96% had an LVEF ≥45%. Multivariable linear regression was used to determine characteristics associated with Kansas City Cardiomyopathy Questionnaire clinical summary score (KCCQ-CSS) and 6MWD. Mean age was 73 ± 8 years, 51% were female, and comorbidities were common. Of the QOL measures tested in PARALLAX, the Short Form Health Survey-36 physical functioning score was most closely correlated with 6MWD (R = 0.41, P < 0.001), and outperformed the KCCQ physical limitation score (R = 0.33) and KCCQ-CSS (R = 0.31) on multivariable analyses. Female sex, higher body mass index, history of coronary artery disease, lower LVEF, and higher N-terminal pro-B-type natriuretic peptide (NT-proBNP) were associated with worse (lower) KCCQ-CSS; older age, female sex, higher body mass index, diabetes, coronary artery disease, chronic obstructive pulmonary disease, prior HF hospitalization, lower LVEF, and higher NT-proBNP were associated with shorter 6MWD (P < 0.05 for all associations). CONCLUSIONS: PARALLAX is the largest HFpEF study to date to examine 6MWD together with QOL. The KCCQ-CSS and 6MWD were modestly correlated, and several factors were associated with worse values of both. These results provide insight into the association between QOL and exercise capacity in HFpEF.","journal":"European Journal of Heart Failure","year":2021,"id":176459,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":21,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9466,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":564261,"name":"Martín Cowie","orcid":"0000-0001-7457-2552","position":1,"is_corresponding":false},{"id":719014,"name":"Rolf Wachter","orcid":"0000-0003-2231-2200","position":2,"is_corresponding":false},{"id":719844,"name":"Peter Szecsödy","orcid":null,"position":3,"is_corresponding":false},{"id":92426,"name":"Victor Shi","orcid":"0000-0002-2533-4379","position":4,"is_corresponding":false},{"id":719845,"name":"Ghionul Ibram","orcid":null,"position":5,"is_corresponding":false},{"id":465004,"name":"Mo Hu","orcid":"0000-0001-6622-0880","position":6,"is_corresponding":false},{"id":719846,"name":"Ziqiang Zhao","orcid":null,"position":7,"is_corresponding":false},{"id":92419,"name":"Jianjian Gong","orcid":"0000-0001-7981-0054","position":8,"is_corresponding":false},{"id":2624,"name":"Burkert Pieske","orcid":"0000-0002-6466-5306","position":9,"is_corresponding":false},{"id":235994,"name":"Sanjiv J. Shah","orcid":"0000-0002-5655-8201","position":0,"is_corresponding":true}],"reference_count":36,"raw_metadata":null,"created_at":"2026-07-18T23:47:23.605867Z","pmid":"34170062","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}