{"doi":"10.1002/ehf2.14101","title":"Prescribed Opioid Use is Associated with Adverse Cardiovascular Outcomes in Community-Dwelling Older Persons","abstract":"AIMS: Prescribed opioids are commonly used in the older community-dwelling population for the treatment of chronic pain. Although the harmful effects of opioid abuse and overdose are well understood, little is known about the long-term cardiovascular (CV) effects of prescribed opioids. The aim of this study was to investigate the CV effects associated with prescribed opioid use. METHODS AND RESULTS: A post hoc analysis of participants in the Aspirin in Reducing Events in the Elderly (ASPREE) trial was conducted. Participants in the ASPREE trial included community-dwelling older adults without a prior history of CV disease (CVD). Prescribed opioid use was defined as opioid use at baseline and/or at the first annual visit (AV1). Cox proportional hazards regression was used to calculate hazard ratios and 95% confidence intervals (95% CI) for associations between opioid use and CVD events following AV1. Of the 17 701 participants included (mean age 75.2 years, 58.2% female), 813 took opioids either at baseline or at AV1. Over a median follow-up period of 3.58 years (IQR 2.50-4.62), CVD events, most notably heart failure hospitalization, occurred in 7% (n = 57) amongst opioid users and 4% (n = 680) amongst non-opioid users. After adjustment for multiple covariates, opiate use was associated with a 1.67-fold (CI 1.26-2.23, P < 0.001) increase in the hazard ratio for CVD events. CONCLUSIONS: These findings identify opioid use as a non-traditional risk factor for CVD events in community-dwelling older adults.","journal":"ESC Heart Failure","year":2022,"id":272050,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":12,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9544,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":42491,"name":"E. Chowdhury","orcid":"0000-0002-9709-794X","position":1,"is_corresponding":false},{"id":104597,"name":"Michael E. Ernst","orcid":"0000-0003-0267-4888","position":2,"is_corresponding":false},{"id":537491,"name":"Julia Gilmartin‐Thomas","orcid":"0000-0002-1783-0161","position":3,"is_corresponding":false},{"id":264296,"name":"Christopher M. Reid","orcid":"0000-0001-9173-3944","position":4,"is_corresponding":false},{"id":284811,"name":"Andrew Tonkin","orcid":"0000-0001-5291-0610","position":5,"is_corresponding":false},{"id":732597,"name":"Franz–Josef Neumann","orcid":"0000-0002-9478-2757","position":6,"is_corresponding":false},{"id":264297,"name":"John J. McNeil","orcid":"0000-0002-1049-5129","position":7,"is_corresponding":false},{"id":937971,"name":"David M. Kaye","orcid":"0000-0003-4058-0372","position":8,"is_corresponding":false},{"id":938619,"name":"Stephanie Liew","orcid":null,"position":0,"is_corresponding":true}],"reference_count":64,"raw_metadata":null,"created_at":"2026-07-19T00:27:43.806977Z","pmid":"35985663","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}