{"doi":"10.1002/dvdy.21336","title":"Transdifferentiation in developmental biology, disease, and in therapy","abstract":"<jats:title>Abstract</jats:title><jats:p>Transdifferentiation (or metaplasia) refers to the conversion of one cell type to another. Because transdifferentiation normally occurs between cells that arise from the same region of the embryo, understanding the molecular and cellular events in cell type transformations may help to explain the mechanisms underlying normal development. Here we review examples of transdifferentiation in nature focusing on the possible role of cell type switching in metamorphosis and regeneration. We also examine transdifferentiation in mammals in relation to disease and the use of transdifferentiated cells in cellular therapy. Developmental Dynamics 236:3208–3217, 2007. © 2007 Wiley‐Liss, Inc.</jats:p>","journal":"Developmental Dynamics","year":2007,"id":593678,"datarank":0.586803450814222,"base_score":3.912023005428146,"endowment":3.912023005428146,"self_citation_contribution":0.586803450814222,"citation_network_contribution":0.0,"self_endowment_contribution":0.586803450814222,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":49,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1519546,"name":"Emily‐Jane Myatt","orcid":null,"position":1,"is_corresponding":false},{"id":148175,"name":"David Tosh","orcid":null,"position":2,"is_corresponding":false},{"id":1519545,"name":"Shifaan Thowfeequ","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Transdifferentiation in developmental biology, disease, and in therapy","abstract":"<jats:title>Abstract</jats:title><jats:p>Transdifferentiation (or metaplasia) refers to the conversion of one cell type to another. Because transdifferentiation normally occurs between cells that arise from the same region of the embryo, understanding the molecular and cellular events in cell type transformations may help to explain the mechanisms underlying normal development. Here we review examples of transdifferentiation in nature focusing on the possible role of cell type switching in metamorphosis and regeneration. We also examine transdifferentiation in mammals in relation to disease and the use of transdifferentiated cells in cellular therapy. Developmental Dynamics 236:3208–3217, 2007. © 2007 Wiley‐Liss, Inc.</jats:p>","is_dataset_classified":null,"base_score":3.912023005428146,"endowment":3.912023005428146,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"17948254","pmcid":null,"openalex_id":"https://openalex.org/W2083068600","authors":[],"funders":[{"funder_name":"Medical Research Council","grant_id":"G0300415","title":null}],"total_grants":1,"fwci":5.0669,"citation_percentile":0.95437196,"influential_citations":0,"citation_trend":[{"year":2012,"count":4},{"year":2013,"count":4},{"year":2014,"count":2},{"year":2015,"count":1},{"year":2016,"count":2},{"year":2018,"count":6},{"year":2020,"count":2},{"year":2021,"count":2},{"year":2022,"count":1},{"year":2023,"count":3}],"oa_status":"bronze","license":"http://onlinelibrary.wiley.com/termsAndConditions#vor","oa_locations":[{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/dvdy.21336","host_type":"journal"},{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/dvdy.21336","host_type":"publisher"},{"url":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fdvdy.21336","host_type":"publisher"},{"url":"https://anatomypubs.onlinelibrary.wiley.com/doi/pdf/10.1002/dvdy.21336","host_type":"publisher"},{"url":"https://doi.org/10.1002/dvdy.21336","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/17948254","host_type":"repository"}],"fields_of_study":["Pancreatic function and diabetes","Pluripotent Stem Cells Research","Congenital heart defects research","Animals","Cell Differentiation","Cell Transdifferentiation","Developmental Biology","Diabetes Mellitus","Disease","Humans","Liver Diseases","Mammals","Metamorphosis, Biological","Metaplasia","Regeneration","Stem Cell Transplantation","Therapeutics"],"mesh_terms":["Animals","Cell Differentiation","Diabetes Mellitus","Disease","Humans","Liver Diseases","Mammals","Metamorphosis, Biological","Metaplasia","Regeneration","Therapeutics","Developmental Biology","Stem Cell Transplantation","Cell Transdifferentiation"],"keywords":["Transdifferentiation","Biology","Cell type","Regeneration (biology)","Cell","Cell biology","Neuroscience","Genetics"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-27T11:53:34.156037Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}