{"doi":"10.1002/dvdy.20966","title":"Localization and requirement for Myosin II at the dorsal‐ventral compartment boundary of the\n                    <i>Drosophila</i>\n                    wing","abstract":"<jats:title>Abstract</jats:title>\n                  <jats:p>\n                    As organisms develop, their tissues can become separated into distinct cell populations through the establishment of compartment boundaries. Compartment boundaries have been discovered in a wide variety of tissues, but in many cases the molecular mechanisms that separate cells remain poorly understood. In the\n                    <jats:italic>Drosophila</jats:italic>\n                    wing, a stripe of Notch activation maintains the dorsal‐ventral compartment boundary, through a process that depends on the actin cytoskeleton. Here, we show that the dorsal‐ventral boundary exhibits a distinct accumulation of Myosin II, and that this accumulation is regulated downstream of Notch signaling. Conversely, the dorsal‐ventral boundary is depleted for the Par‐3 homologue Bazooka. We further show that mutations in the Myosin heavy chain subunit encoded by\n                    <jats:italic>zipper</jats:italic>\n                    can impair dorsal‐ventral compartmentalization without affecting anterior‐posterior compartmentalization. These observations identify a distinct accumulation and requirement for Myosin activity in dorsal‐ventral compartmentalization, and suggest a novel mechanism in which contractile tension along an F‐actin cable at the compartment boundary contributes to compartmentalization. Developmental Dynamics 235:3051–3058, 2006. © 2006 Wiley‐Liss, Inc.\n                  </jats:p>","journal":"Developmental Dynamics","year":2006,"id":632554,"datarank":0.7433740586401892,"base_score":4.955827057601261,"endowment":4.955827057601261,"self_citation_contribution":0.7433740586401892,"citation_network_contribution":0.0,"self_endowment_contribution":0.7433740586401892,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":141,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":249879,"name":"Kenneth D. Irvine","orcid":"0000-0002-0515-3562","position":1,"is_corresponding":false},{"id":1621340,"name":"Robert J. Major","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Localization and requirement for Myosin II at the dorsal‐ventral compartment boundary of the\n                    <i>Drosophila</i>\n                    wing","abstract":"<jats:title>Abstract</jats:title>\n                  <jats:p>\n                    As organisms develop, their tissues can become separated into distinct cell populations through the establishment of compartment boundaries. Compartment boundaries have been discovered in a wide variety of tissues, but in many cases the molecular mechanisms that separate cells remain poorly understood. In the\n                    <jats:italic>Drosophila</jats:italic>\n                    wing, a stripe of Notch activation maintains the dorsal‐ventral compartment boundary, through a process that depends on the actin cytoskeleton. Here, we show that the dorsal‐ventral boundary exhibits a distinct accumulation of Myosin II, and that this accumulation is regulated downstream of Notch signaling. Conversely, the dorsal‐ventral boundary is depleted for the Par‐3 homologue Bazooka. We further show that mutations in the Myosin heavy chain subunit encoded by\n                    <jats:italic>zipper</jats:italic>\n                    can impair dorsal‐ventral compartmentalization without affecting anterior‐posterior compartmentalization. These observations identify a distinct accumulation and requirement for Myosin activity in dorsal‐ventral compartmentalization, and suggest a novel mechanism in which contractile tension along an F‐actin cable at the compartment boundary contributes to compartmentalization. Developmental Dynamics 235:3051–3058, 2006. © 2006 Wiley‐Liss, Inc.\n                  </jats:p>","is_dataset_classified":null,"base_score":4.955827057601261,"endowment":4.955827057601261,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"17013876","pmcid":null,"openalex_id":"https://openalex.org/W2032419889","authors":[],"funders":[{"funder_name":"NIGMS NIH HHS","grant_id":"R01 GM54594","title":null}],"total_grants":1,"fwci":1.8858,"citation_percentile":0.84159483,"influential_citations":0,"citation_trend":[{"year":2012,"count":8},{"year":2013,"count":9},{"year":2014,"count":8},{"year":2015,"count":10},{"year":2016,"count":6},{"year":2017,"count":10},{"year":2018,"count":5},{"year":2019,"count":9},{"year":2020,"count":10},{"year":2021,"count":5},{"year":2022,"count":5},{"year":2023,"count":10},{"year":2024,"count":2},{"year":2025,"count":9},{"year":2026,"count":2}],"oa_status":"bronze","license":"http://onlinelibrary.wiley.com/termsAndConditions#vor","oa_locations":[{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/dvdy.20966","host_type":"journal"},{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/dvdy.20966","host_type":"publisher"},{"url":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fdvdy.20966","host_type":"publisher"},{"url":"https://anatomypubs.onlinelibrary.wiley.com/doi/pdf/10.1002/dvdy.20966","host_type":"publisher"},{"url":"https://doi.org/10.1002/dvdy.20966","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/17013876","host_type":"repository"}],"fields_of_study":["Cellular Mechanics and Interactions","Developmental Biology and Gene Regulation","Hippo pathway signaling and YAP/TAZ"],"mesh_terms":["Animals","Drosophila","Membrane Proteins","Mutation","Wings, Animal","Myosin Heavy Chains","Myosin Type II","Drosophila Proteins","Intracellular Signaling Peptides and Proteins","Receptors, Notch"],"keywords":["Compartment (ship)","Compartmentalization (fire protection)","Biology","Myosin","Cell biology","Actin","Anatomy","Cytoskeleton","Dorsum","Cell","Genetics","Biochemistry"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Life below water"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-06T09:58:45.748038Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}