{"doi":"10.1002/dad2.70168","title":"Lower odor identification in subjective cognitive decline: a meta‐analysis","abstract":"INTRODUCTION: Odor identification correlates with Alzheimer's disease (AD) biomarkers, and its decline may emerge before measurable cognitive deficits - as early as the subjective cognitive decline (SCD) stage. We aimed to compare odor identification between SCD and cognitively normal (CN) stages. METHODS: A systematic search of four databases identified studies assessing olfactory identification and cognitive screening in individuals aged 50+. A random-effects meta-analysis was performed on 11 studies (660 SCD, 574 CN). RESULTS: = 0.02) between cognitive and olfactory differences; lower olfactory identification scores in SCD occurred despite minimal cognitive differences across groups. DISCUSSION: Odor identification is lower in pre-mild cognitive impairment individuals reporting SCD. Olfactory decline may emerge prior to measurable general cognitive decline, supporting its role as a screen for AD. Highlights: Individuals with SCD exhibit lower odor identification scores.Olfactory identification may serve as an early marker of neurodegeneration in preclinical AD.Heterogeneity highlights the need for multimodal biomarker approaches.","journal":"Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring","year":2025,"id":521892,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9489,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1392810,"name":"Coline Zigrand","orcid":"0000-0002-9691-6261","position":1,"is_corresponding":false},{"id":624231,"name":"Johannes Frasnelli","orcid":"0000-0002-8863-3982","position":2,"is_corresponding":false},{"id":1392811,"name":"Benjamin Boller","orcid":"0000-0002-6184-1933","position":3,"is_corresponding":false},{"id":231554,"name":"Mark W. Albers","orcid":"0000-0001-7855-3455","position":4,"is_corresponding":false},{"id":1380642,"name":"Benoît Jobin","orcid":"0000-0002-1357-5116","position":0,"is_corresponding":true}],"reference_count":49,"raw_metadata":null,"created_at":"2026-07-19T02:49:49.198144Z","pmid":"40827140","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}