{"doi":"10.1002/dad2.70134","title":"Dysregulation of cerebral perfusion dynamics is associated with Alzheimer's disease","abstract":"INTRODUCTION: A novel physio-marker, termed \"cerebrovascular dynamics index\" (CDI), was developed and evaluated in a multi-center National Institutes of Health (NIH)-funded study for improved diagnosis of mild cognitive impairment (MCI) and its transition to Alzheimer's disease (AD). METHODS: The CDI quantifies the regulation dynamics of cerebral perfusion and oxygenation (which adjust autonomously blood flow and oxygen delivery over time) through predictive dynamic modeling using relevant time-series data. RESULTS: Cross-sectional results demonstrated excellent diagnostic performance of CDI in differentiating 90 MCI/AD patients from 77 controls (area under the curve (AUC) = 0.96), which surpassed the commonly used biomarker of amyloid positron emission tomography-standardized uptake value ratio (PET-SUVR) (AUC = 0.78) or cognitive screening tests of Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) (AUC = 0.91 and 0.92, respectively). The CDI can also be used for disease staging because it differentiated 56 MCI from 34 mild AD participants (AUC = 0.98). CONCLUSION: These findings offer the promise of a high-performance diagnostic physio-marker for MCI and AD, which can be obtained in a comfortable, rapid, and automated manner in clinical settings. Highlights: Novel physio-marker (cerebrovascular dynamics index [CDI]) quantifies the regulation dynamics of cerebral perfusion.The CDI was shown to improve mild cognitive impairment/Alzheimer's disease (MCI/AD) diagnosis (area under the curve [AUC] >0.95) relative to existing markers.The CDI is obtained non-invasively, objectively, rapidly, and inexpensively.The CDI performance supports the key role of cerebrovascular dysfunction in AD.The CDI is obtained via dynamic modeling of hemodynamic/oxygenation time-series data.","journal":"Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring","year":2025,"id":570685,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9464,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1476570,"name":"Sandy Billinger","orcid":null,"position":1,"is_corresponding":false},{"id":288639,"name":"Elizabeth Joe","orcid":"0000-0002-5222-0772","position":2,"is_corresponding":false},{"id":518637,"name":"Dae C. Shin","orcid":null,"position":3,"is_corresponding":false},{"id":1476571,"name":"Suhaib Hashem","orcid":null,"position":4,"is_corresponding":false},{"id":1353020,"name":"Jasmin Rizko","orcid":null,"position":5,"is_corresponding":false},{"id":1179435,"name":"E. Hazen","orcid":"0009-0005-6058-4129","position":6,"is_corresponding":false},{"id":525676,"name":"Danilo Cardim","orcid":"0000-0002-9261-1321","position":7,"is_corresponding":false},{"id":1418670,"name":"Jeff Burns","orcid":null,"position":8,"is_corresponding":false},{"id":348513,"name":"Rong Zhang","orcid":"0000-0002-6534-5216","position":9,"is_corresponding":false},{"id":281098,"name":"Helena C. Chui","orcid":"0000-0003-1348-0931","position":10,"is_corresponding":false},{"id":1476569,"name":"Vasilis Marmarelis","orcid":null,"position":0,"is_corresponding":true}],"reference_count":47,"raw_metadata":null,"created_at":"2026-07-19T02:57:11.713851Z","pmid":"40689334","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}