{"doi":"10.1002/dad2.70110","title":"Cerebrospinal fluid YKL‐40 relates to white matter hyperintensity progression in females but not males over a 6‐year period","abstract":"INTRODUCTION: Neuroinflammation may have sex-specific effects on white matter injury and impact the development of dementia. METHODS: Human chitinase-3-like protein-1 (YKL-40) concentrations at baseline were related to white matter hyperintensity (WMH) volume, free water (FW), and FW-corrected fractional anisotropy using linear effects models (for cross-sectional outcomes) and linear mixed-effects models (for longitudinal outcomes), adjusting for demographic and medical risk factors. Models were repeated with a sex-interaction term and then stratified by sex. RESULTS: = 0.71) longitudinally. YKL-40 associations with FW and FW-corrected fractional anisotropy were null. DISCUSSION: Results suggest that neuroinflammation is a sex-specific driver of WMHs (but not FW) in females. Differential sequelae of neuroinflammation may be one reason that females have a greater burden of WMHs. Highlights: ·Cerebrospinal fluid YKL-40 is associated with white matter hyperintensities in females but not males cross-sectionally and longitudinally.·Longitudinally, cerebrospinal fluid YKL-40 is associated with white matter hyperintensities in the parietal and temporal lobes, regions that exhibit early pathological changes in Alzheimer's disease .·Cerebrospinal fluid YKL-40 is not associated with white matter microstructural measures.","journal":"Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring","year":2025,"id":544122,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9499,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1368875,"name":"Yunyi Sun","orcid":null,"position":1,"is_corresponding":false},{"id":463985,"name":"Derek B. Archer","orcid":"0000-0001-8638-0785","position":2,"is_corresponding":false},{"id":1396473,"name":"Hailey A. Adegboye","orcid":null,"position":3,"is_corresponding":false},{"id":389624,"name":"Elizabeth E. Moore","orcid":null,"position":4,"is_corresponding":false},{"id":1434399,"name":"Isabella Deberghes","orcid":null,"position":5,"is_corresponding":false},{"id":388775,"name":"Kimberly R. Pechman","orcid":"0000-0003-0596-8064","position":6,"is_corresponding":false},{"id":464786,"name":"Niranjana Shashikumar","orcid":null,"position":7,"is_corresponding":false},{"id":676972,"name":"W Hudson Robb","orcid":"0000-0002-8952-7719","position":8,"is_corresponding":false},{"id":1384166,"name":"Abigail W. Workmeister","orcid":null,"position":9,"is_corresponding":false},{"id":942898,"name":"T. Bryan Jackson","orcid":"0000-0002-6318-1916","position":10,"is_corresponding":false},{"id":1433951,"name":"Dandan Liu","orcid":"0000-0002-4635-0087","position":11,"is_corresponding":false},{"id":261835,"name":"Logan Dumitrescu","orcid":"0000-0002-9782-9944","position":12,"is_corresponding":false},{"id":363943,"name":"L. Taylor Davis","orcid":"0000-0003-2939-3875","position":13,"is_corresponding":false},{"id":104551,"name":"Bennett A. Landman","orcid":"0000-0001-5733-2127","position":14,"is_corresponding":false},{"id":27600,"name":"Kaj Blennow","orcid":"0000-0002-1890-4193","position":15,"is_corresponding":false},{"id":27601,"name":"Henrik Zetterberg","orcid":"0000-0003-3930-4354","position":16,"is_corresponding":false},{"id":254761,"name":"Timothy J. Hohman","orcid":"0000-0002-3377-7014","position":17,"is_corresponding":false},{"id":261853,"name":"Angela L. Jefferson","orcid":"0000-0002-8245-0587","position":18,"is_corresponding":false},{"id":696426,"name":"Amalia Peterson","orcid":"0000-0002-7015-7957","position":0,"is_corresponding":true}],"reference_count":49,"raw_metadata":null,"created_at":"2026-07-19T02:53:08.338070Z","pmid":"40352684","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}