{"doi":"10.1002/dad2.70105","title":"Rest‐activity rhythm characteristics associated with lower cognitive performance and Alzheimer's disease biomarkers in midlife women","abstract":"INTRODUCTION: Disrupted rest-activity rhythms (RARs) have been linked to poorer cognitive function and Alzheimer's disease (AD) biomarkers. Here we extend this work to midlife women, who commonly experience menopause-related sleep and cognitive problems. METHODS: One hundred ninety-four postmenopausal participants underwent a neuropsychological evaluation, 72 h of wrist actigraphy generating RAR variables, and a blood draw to measure AD biomarkers: phosphorylated tau (p-tau181, p-tau231) and amyloid beta (Aβ40, Aβ42). RESULTS: Lower interdaily stability (IS) and relative amplitude (RA) and higher interdaily variability (IV) and least active 5 h (L5) were associated with worse processing speed, independent of sleep. Adjustment for sleep significantly attenuated the associations of RA with memory. Lower RA was associated with higher p-tau231 level, independent of sleep. Further adjustment for menopause-related factors modestly accounted for the associations between RAR, cognitive measures, and AD biomarkers. DISCUSSION: Weaker RAR, particularly RA, was associated with worse cognitive functions, and higher AD biomarkers levels, possibly linking RAR with AD pathology in women. Highlights: Lower rhythm stability and robustness and higher fragmentation were associated with worse processing speed.Lower robustness was associated with higher levels of phosphorylated tau-231.Menopause factors did not attenuate the association between rest-activity rhythms and cognitive function.","journal":"Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring","year":2025,"id":552400,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9209,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":341542,"name":"Rebecca C. Thurston","orcid":"0000-0001-6580-1202","position":1,"is_corresponding":false},{"id":312682,"name":"Stephen F. Smagula","orcid":"0000-0002-5881-4803","position":2,"is_corresponding":false},{"id":129015,"name":"Yue-Fang Chang","orcid":null,"position":3,"is_corresponding":false},{"id":104956,"name":"Pauline M. Maki","orcid":"0000-0002-8443-3430","position":4,"is_corresponding":false},{"id":1448522,"name":"Alexandra Paget‐Blanc","orcid":"0009-0007-6615-8854","position":0,"is_corresponding":true}],"reference_count":47,"raw_metadata":null,"created_at":"2026-07-19T02:54:33.203144Z","pmid":"40242837","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}