{"doi":"10.1002/dad2.70089","title":"Amyloid is associated with accelerated atrophy in cognitively unimpaired individuals","abstract":"INTRODUCTION: This study examined the association of longitudinal atrophy with baseline cerebrospinal fluid (CSF) amyloid beta (Aβ, A) and phosphorylated tau (p-tau, T) biomarkers (Aβ42/40, p-tau181) in 406 cognitively unimpaired (CU) individuals (6.670 years of follow-up on average, up to 13 imaging visits) to assess whether A+ is associated with Alzheimer's disease-like atrophy and whether this depends on p-tau181 levels. METHODS: -scoring. Linear mixed-effects models tested differences in longitudinal atrophy between A+ and A-T-N- individuals and between A/T subgroups. RESULTS: A+ was associated with worse atrophy within and beyond the medial temporal lobe, even at low levels of p-tau181. DISCUSSION: Neurodegeneration likely begins soon after the onset of abnormal Aβ pathology. Clinical intervention at the earliest signs of Aβ pathology may be needed to mitigate further neurodegeneration. Highlights: An A-T-N- control group was identified using a robust normative approachA+ was associated with accelerated atrophy in cognitively unimpaired individualsAtrophy was observed even at low p-tau181 levels.","journal":"Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring","year":2025,"id":550230,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9281,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":289688,"name":"Tobey J. Betthauser","orcid":"0000-0001-8856-1352","position":1,"is_corresponding":false},{"id":1019298,"name":"Rebecca Langhough","orcid":null,"position":2,"is_corresponding":false},{"id":289689,"name":"Erin M. Jonaitis","orcid":"0009-0004-5091-8255","position":3,"is_corresponding":false},{"id":340627,"name":"Lianlian Du","orcid":null,"position":4,"is_corresponding":false},{"id":429176,"name":"Carol Van Hulle","orcid":null,"position":5,"is_corresponding":false},{"id":671639,"name":"Gwendlyn Kollmorgen","orcid":null,"position":6,"is_corresponding":false},{"id":1234121,"name":"Clara Quijano‐Rubio","orcid":"0000-0001-9050-3282","position":7,"is_corresponding":false},{"id":289693,"name":"Nathaniel A. Chin","orcid":"0000-0001-8008-9356","position":8,"is_corresponding":false},{"id":493820,"name":"Ozioma C. Okonkwo","orcid":"0000-0001-5803-6055","position":9,"is_corresponding":false},{"id":289694,"name":"Cynthia M. Carlsson","orcid":"0000-0001-5743-1563","position":10,"is_corresponding":false},{"id":289695,"name":"Sanjay Asthana","orcid":"0000-0002-3998-4479","position":11,"is_corresponding":false},{"id":230038,"name":"Sterling C. Johnson","orcid":"0000-0002-8501-545X","position":12,"is_corresponding":false},{"id":27600,"name":"Kaj Blennow","orcid":"0000-0002-1890-4193","position":13,"is_corresponding":false},{"id":27601,"name":"Henrik Zetterberg","orcid":"0000-0003-3930-4354","position":14,"is_corresponding":false},{"id":291168,"name":"Barbara B. Bendlin","orcid":"0000-0002-0580-9875","position":15,"is_corresponding":false},{"id":1172114,"name":"Henry Gilreath Stephenson","orcid":"0000-0002-8340-1162","position":0,"is_corresponding":true}],"reference_count":51,"raw_metadata":null,"created_at":"2026-07-19T02:54:16.596730Z","pmid":"39996035","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}