{"doi":"10.1002/dad2.12560","title":"Social relationships, amyloid burden, and dementia: The ARIC‐PET study","abstract":"INTRODUCTION: This study aimed to assess whether social relationships in mid-life reduce the risk of dementia related to amyloid burden. METHODS: Participants in the Atherosclerosis Risk in Communities (ARIC) study were assessed for social support and isolation (visit 2; 1990-1992). A composite measure, \"social relationships,\" was generated. Brain amyloid was evaluated with florbetapir positron emission tomography (PET); (visit 5; 2012-2014). Incident dementia cases were identified following visit 5 through 2019 using ongoing surveillance. Relative contributions of mid-life social relationships and elevated brain amyloid to incident dementia were evaluated with Cox regression models. RESULTS: Among 310 participants without dementia, strong mid-life social relationships were associated independently with lower dementia risk. Elevated late-life brain amyloid was associated with greater dementia risk. DISCUSSION: Although mid-life social relationships did not moderate the relationship between amyloid burden and dementia, these findings affirm the importance of strong social relationships as a potentially protective factor against dementia.","journal":"Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring","year":2024,"id":454333,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9293,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1257286,"name":"Albert C. Liu","orcid":"0000-0003-0777-4431","position":1,"is_corresponding":false},{"id":676764,"name":"Chelsea Liu","orcid":"0000-0001-9942-9955","position":2,"is_corresponding":false},{"id":49955,"name":"David S. Knopman","orcid":"0000-0002-6544-066X","position":3,"is_corresponding":false},{"id":344823,"name":"Silvia Koton","orcid":"0000-0002-9327-7505","position":4,"is_corresponding":false},{"id":402436,"name":"Anna Kucharska‐Newton","orcid":"0000-0001-9864-467X","position":5,"is_corresponding":false},{"id":98923,"name":"Pamela L. Lutsey","orcid":"0000-0002-1572-1340","position":6,"is_corresponding":false},{"id":73351,"name":"Thomas H. Mosley","orcid":"0000-0003-3343-1352","position":7,"is_corresponding":false},{"id":370391,"name":"Priya Palta","orcid":null,"position":8,"is_corresponding":false},{"id":699682,"name":"A. Richey Sharrett","orcid":"0000-0002-8835-7770","position":9,"is_corresponding":false},{"id":34922,"name":"Keenan A. Walker","orcid":"0000-0002-5989-9853","position":10,"is_corresponding":false},{"id":342706,"name":"Dean F. Wong","orcid":"0000-0001-9343-8367","position":11,"is_corresponding":false},{"id":328345,"name":"Rebecca F. Gottesman","orcid":"0000-0002-9504-1256","position":12,"is_corresponding":false},{"id":1110577,"name":"Renée C. Groechel","orcid":"0000-0002-1771-5171","position":0,"is_corresponding":true}],"reference_count":42,"raw_metadata":null,"created_at":"2026-07-19T02:03:07.923686Z","pmid":"38571965","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}