{"doi":"10.1002/dad2.12455","title":"Harmonized multi‐metric and multi‐centric assessment of EEG source space connectivity for dementia characterization","abstract":"Introduction: Harmonization protocols that address batch effects and cross-site methodological differences in multi-center studies are critical for strengthening electroencephalography (EEG) signatures of functional connectivity (FC) as potential dementia biomarkers. Methods: We implemented an automatic processing pipeline incorporating electrode layout integrations, patient-control normalizations, and multi-metric EEG source space connectomics analyses. Results: Spline interpolations of EEG signals onto a head mesh model with 6067 virtual electrodes resulted in an effective method for integrating electrode layouts. Z-score transformations of EEG time series resulted in source space connectivity matrices with high bilateral symmetry, reinforced long-range connections, and diminished short-range functional interactions. A composite FC metric allowed for accurate multicentric classifications of Alzheimer's disease and behavioral variant frontotemporal dementia. Discussion: Harmonized multi-metric analysis of EEG source space connectivity can address data heterogeneities in multi-centric studies, representing a powerful tool for accurately characterizing dementia.","journal":"Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring","year":2023,"id":333380,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":23,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8884,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1019878,"name":"Jhony Mejia","orcid":"0000-0002-0313-6902","position":1,"is_corresponding":false},{"id":1019020,"name":"Agustín Sainz‐Ballesteros","orcid":null,"position":2,"is_corresponding":false},{"id":282303,"name":"Agustina Birba","orcid":"0000-0001-5998-6634","position":3,"is_corresponding":false},{"id":262294,"name":"Sebastián Moguilner","orcid":"0000-0003-1731-8325","position":4,"is_corresponding":false},{"id":848614,"name":"Rubén Herzog","orcid":"0000-0002-3498-5819","position":5,"is_corresponding":false},{"id":1056422,"name":"Mónica Otero","orcid":"0000-0001-7254-9244","position":6,"is_corresponding":false},{"id":993502,"name":"Jhosmary Cuadros","orcid":"0000-0001-7665-0171","position":7,"is_corresponding":false},{"id":993501,"name":"Lucía Z‐Rivera","orcid":"0000-0001-9243-193X","position":8,"is_corresponding":false},{"id":1061172,"name":"Daniel Franco O'Byrne","orcid":null,"position":9,"is_corresponding":false},{"id":262247,"name":"Mario A. Parra","orcid":"0000-0002-2412-648X","position":10,"is_corresponding":false},{"id":282310,"name":"Agustín Ibáñez","orcid":"0000-0001-6758-5101","position":11,"is_corresponding":false},{"id":683731,"name":"Pavel Prado","orcid":"0000-0002-1324-6400","position":0,"is_corresponding":true}],"reference_count":55,"raw_metadata":null,"created_at":"2026-07-19T01:09:39.719497Z","pmid":"37424962","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}