{"doi":"10.1002/dad2.12434","title":"Operationalizing the centiloid scale for [<sup>18</sup>F]florbetapir PET studies on PET/MRI","abstract":"INTRODUCTION: The Centiloid scale aims to harmonize amyloid beta (Aβ) positron emission tomography (PET) measures across different analysis methods. As Centiloids were created using PET/computerized tomography (CT) data and are influenced by scanner differences, we investigated the Centiloid transformation with data from Insight 46 acquired with PET/magnetic resonanceimaging (MRI). METHODS: We transformed standardized uptake value ratios (SUVRs) from 432 florbetapir PET/MRI scans processed using whole cerebellum (WC) and white matter (WM) references, with and without partial volume correction. Gaussian-mixture-modelling-derived cutpoints for Aβ PET positivity were converted. RESULTS: The Centiloid cutpoint was 14.2 for WC SUVRs. The relationship between WM and WC uptake differed between the calibration and testing datasets, producing implausibly low WM-based Centiloids. Linear adjustment produced a WM-based cutpoint of 18.1. DISCUSSION: Transformation of PET/MRI florbetapir data to Centiloids is valid. However, further understanding of the effects of acquisition or biological factors on the transformation using a WM reference is needed. HIGHLIGHTS: Centiloid conversion of amyloid beta positron emission tomography (PET) data aims to standardize results.Centiloid values can be influenced by differences in acquisition.We converted florbetapir PET/magnetic resonance imaging data from a large birth cohort.Whole cerebellum referenced values could be reliably transformed to Centiloids.White matter referenced values may be less generalizable between datasets.","journal":"Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring","year":2023,"id":337261,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":18,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.5646,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":534810,"name":"Marc Modat","orcid":"0000-0002-5277-8530","position":1,"is_corresponding":false},{"id":104558,"name":"M. Jorge Cardoso","orcid":"0000-0003-1284-2558","position":2,"is_corresponding":false},{"id":1068577,"name":"Paweł Markiewicz","orcid":"0000-0002-3114-0773","position":3,"is_corresponding":false},{"id":406191,"name":"Christopher Lane","orcid":"0000-0003-2945-9352","position":4,"is_corresponding":false},{"id":447579,"name":"Thomas D. Parker","orcid":"0000-0001-7679-4220","position":5,"is_corresponding":false},{"id":447581,"name":"Ashvini Keshavan","orcid":"0000-0003-1043-5721","position":6,"is_corresponding":false},{"id":447578,"name":"Sarah M. Buchanan","orcid":"0000-0001-9175-936X","position":7,"is_corresponding":false},{"id":447582,"name":"Sarah E Keuss","orcid":"0000-0002-7403-281X","position":8,"is_corresponding":false},{"id":296326,"name":"Matthew Harris","orcid":"0000-0001-5785-4830","position":9,"is_corresponding":false},{"id":648084,"name":"Ninon Burgos","orcid":"0000-0002-4668-2006","position":10,"is_corresponding":false},{"id":1068578,"name":"John Dickson","orcid":"0000-0002-1793-3822","position":11,"is_corresponding":false},{"id":1068579,"name":"Anna Barnes","orcid":"0000-0002-6902-214X","position":12,"is_corresponding":false},{"id":12944,"name":"David L. Thomas","orcid":"0000-0003-1491-1641","position":13,"is_corresponding":false},{"id":1068580,"name":"Daniel Beasley","orcid":"0000-0003-1433-9016","position":14,"is_corresponding":false},{"id":67955,"name":"Ian B. Malone","orcid":"0000-0001-7512-7856","position":15,"is_corresponding":false},{"id":21850,"name":"Andrew Wong","orcid":"0000-0003-2079-4779","position":16,"is_corresponding":false},{"id":1068581,"name":"Kjell Erlandsson","orcid":"0000-0002-1072-4382","position":17,"is_corresponding":false},{"id":1068582,"name":"Benjamin A. Thomas","orcid":"0000-0002-9784-1177","position":18,"is_corresponding":false},{"id":241109,"name":"Michael Schöll","orcid":"0000-0001-7800-1781","position":19,"is_corresponding":false},{"id":104583,"name":"Sébastien Ourselin","orcid":"0000-0002-5694-5340","position":20,"is_corresponding":false},{"id":447587,"name":"Marcus Richards","orcid":"0000-0001-9191-2192","position":21,"is_corresponding":false},{"id":66357,"name":"Nick C. Fox","orcid":"0000-0002-6660-657X","position":22,"is_corresponding":false},{"id":241105,"name":"Thomas K. Karikari","orcid":"0000-0003-1422-4358","position":23,"is_corresponding":false},{"id":320896,"name":"David M. Cash","orcid":"0000-0001-7833-616X","position":24,"is_corresponding":false},{"id":300139,"name":"for the Alzheimer's Disease Neuroimaging Initiative","orcid":null,"position":25,"is_corresponding":false},{"id":447586,"name":"William Coath","orcid":"0000-0002-3976-9461","position":0,"is_corresponding":true}],"reference_count":47,"raw_metadata":null,"created_at":"2026-07-19T01:10:26.690308Z","pmid":"37201176","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}