{"doi":"10.1002/dad2.12371","title":"The relationship between Alzheimer's‐related brain atrophy patterns and sleep macro‐architecture","abstract":"Introduction: Sleep is increasingly recognized as a major risk factor for neurodegenerative disorders such as Alzheimer's disease (AD). Methods: Using an magnetic resonance imaging (MRI)-based AD score based on clinical data from the Alzheimer's Disease Neuroimaging Initiative 1 (ADNI1) case-control cohort, we investigated the associations between polysomnography-based sleep macro-architecture and AD-related brain atrophy patterns in 712 pre-symptomatic, healthy subjects from the population-based Study of Health in Pomerania. Results: We identified a robust inverse association between slow-wave sleep and the AD marker (estimate: -0.019; 95% confidence interval: -0.03 to -0.0076; false discovery rate [FDR] = 0.0041), as well as with gray matter (GM) thicknesses in typical individual cortical AD-signature regions. No effects were identified regarding rapid eye movement or non-rapid eye movement (NREM) stage 2 sleep, and NREM stage 1 was positively associated with GM thickness, mainly in the prefrontal cortical regions. Discussion: There is a cross-sectional relationship between AD-related neurodegenerative patterns and the proportion of sleep spent in slow-wave sleep.","journal":"Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring","year":2022,"id":261539,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":15,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9595,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":235032,"name":"Stefan Frenzel","orcid":"0000-0001-5087-5970","position":1,"is_corresponding":false},{"id":916380,"name":"Linda Garvert","orcid":"0000-0001-9067-8170","position":2,"is_corresponding":false},{"id":916381,"name":"Annemarie Luise Kühn","orcid":"0000-0002-0158-8286","position":3,"is_corresponding":false},{"id":235067,"name":"Katharina Wittfeld","orcid":"0000-0003-4383-5043","position":4,"is_corresponding":false},{"id":268147,"name":"Ralf Ewert","orcid":"0000-0002-6746-9925","position":5,"is_corresponding":false},{"id":372148,"name":"Ingo Fietze","orcid":"0000-0001-5567-5206","position":6,"is_corresponding":false},{"id":372151,"name":"Thomas Penzel","orcid":"0000-0002-4304-0112","position":7,"is_corresponding":false},{"id":268148,"name":"Beate Stubbe","orcid":"0000-0002-7571-744X","position":8,"is_corresponding":false},{"id":458615,"name":"András Szentkirályi","orcid":"0000-0002-7892-2422","position":9,"is_corresponding":false},{"id":916382,"name":"Niklas Wulms","orcid":"0000-0002-3418-9978","position":10,"is_corresponding":false},{"id":5359,"name":"Henry Völzke","orcid":"0000-0001-7003-399X","position":11,"is_corresponding":false},{"id":5329,"name":"Hans J. Grabe","orcid":"0000-0003-3684-4208","position":12,"is_corresponding":false},{"id":458614,"name":"Antoine Weihs","orcid":"0000-0002-7113-0027","position":0,"is_corresponding":true}],"reference_count":46,"raw_metadata":null,"created_at":"2026-07-19T00:26:16.663144Z","pmid":"36381559","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}