{"doi":"10.1002/dad2.12351","title":"Associations of the Lifestyle for Brain Health index with longitudinal cognition and brain amyloid beta in clinically unimpaired older adults: Findings from the Wisconsin Registry for Alzheimer's Prevention","abstract":"Introduction: Modifiable health and lifestyle factors increase risk of dementia, but whether modifiable factors, when measured in late-midlife, impact the emergence or progression of Alzheimer's disease (AD) pathophysiologic or cognitive changes remains unresolved. Methods: = 1215; baseline age, M [standard deviation] = 59.3 [6.7] years) from the Wisconsin Registry for Alzheimer's Prevention (WRAP), we investigated the influence of the Lifestyle for Brain Health (LIBRA) index, a lifestyle-based dementia risk score, on AD-related cognitive trajectories and amyloid beta (Aβ) plaque accumulation. Results: Overall, lower baseline LIBRA, denoting healthier lifestyle and lower dementia risk, was related to better overall cognitive performance, but did not moderate apolipoprotein E ε4 or Aβ-related longitudinal cognitive trajectories. LIBRA was not significantly associated with Aβ accumulation or estimated age of Aβ onset. Discussion: In WRAP, late-midlife LIBRA scores were related to overall cognitive performance, but not AD-related cognitive decline or Aβ accumulation in the preclinical timeframe. Highlights: The Lifestyle for Brain Health (LIBRA) index was associated with cognitive performance in late-midlife.LIBRA did not moderate apolipoprotein E ε4 or amyloid-related cognitive decline.LIBRA was not associated with the onset or accumulation of amyloid plaques.","journal":"Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring","year":2022,"id":256774,"datarank":0.575891852238297,"base_score":2.995732273553991,"endowment":2.995732273553991,"self_citation_contribution":0.4493598410330987,"citation_network_contribution":0.12653201120519833,"self_endowment_contribution":0.4493598410330987,"citer_contribution":0.12653201120519833,"corpus_percentile":65.94724220623502,"corpus_rank":4403,"citation_count":19,"citer_count":11,"citers_with_citation_signal":6,"citers_with_endowment":6,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":0.5407,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":289687,"name":"Rebecca L. Koscik","orcid":"0000-0003-0025-744X","position":1,"is_corresponding":false},{"id":906093,"name":"Claire M. Erickson","orcid":"0000-0003-0392-0198","position":2,"is_corresponding":false},{"id":494766,"name":"Sara E. Berman","orcid":null,"position":3,"is_corresponding":false},{"id":289689,"name":"Erin M. Jonaitis","orcid":"0009-0004-5091-8255","position":4,"is_corresponding":false},{"id":347138,"name":"Victoria J. Williams","orcid":"0000-0003-1834-3987","position":5,"is_corresponding":false},{"id":311269,"name":"Kimberly D. Mueller","orcid":"0000-0001-8691-9517","position":6,"is_corresponding":false},{"id":270461,"name":"Bradley T. Christian","orcid":"0000-0002-9653-559X","position":7,"is_corresponding":false},{"id":906645,"name":"Nathanial A. Chin","orcid":null,"position":8,"is_corresponding":false},{"id":289690,"name":"Lindsay R. Clark","orcid":"0000-0003-4837-7627","position":9,"is_corresponding":false},{"id":289688,"name":"Tobey J. Betthauser","orcid":"0000-0001-8856-1352","position":10,"is_corresponding":false},{"id":230038,"name":"Sterling C. Johnson","orcid":"0000-0002-8501-545X","position":11,"is_corresponding":false},{"id":289692,"name":"Karly Alex Cody","orcid":"0000-0001-5996-2560","position":0,"is_corresponding":true}],"reference_count":41,"raw_metadata":null,"created_at":"2026-07-19T00:25:25.728895Z","pmid":"36110432","pmcid":"PMC9464997","fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}