{"doi":"10.1002/dad2.12338","title":"Retinal arteriolar parameters as a surrogate marker of intracranial vascular pathology","abstract":"Introduction: Development of novel diagnostic tools is a top research priority in vascular dementia. A major obstacle is the lack of a simple, non-invasive method to visualize cerebral arteriolar walls in vivo. Retinal arterioles offer a window into the cerebral circulation. Methods: ptical coherence tomography (I-bRAVO) was applied to evaluate mean wall thickness (MWT) and wall-to-lumen ratio (WLR) in 250 subjects with sporadic and genetic cerebral small vessel disease (CSVD), non-vascular neurodegenerative diseases (NVND), and healthy controls (HC) in association with imaging and cognitive markers. Results: MWT and WLR were higher in CSVD, associated with severity of vascular white matter lesions, and correlated with magnetic resonance imaging-based intracranial arteriolosclerosis score. WLR correlated with gray and white matter volume and differentiated asymptomatic sporadic CSVD from HC (area under the curve = 0.82). Discussion: I-bRAVO is a rapid, non-invasive tool. MWT and WLR were associated with imaging markers of CSVD and could contribute to early identification of sporadic CSVD.","journal":"Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring","year":2022,"id":286491,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9641,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":79609,"name":"Isaac H. Solomon","orcid":"0000-0003-3432-0902","position":1,"is_corresponding":false},{"id":965788,"name":"Shivany Condor Montes","orcid":"0000-0003-1211-6046","position":2,"is_corresponding":false},{"id":966254,"name":"Alexandra Saias","orcid":null,"position":3,"is_corresponding":false},{"id":482694,"name":"Christian Cordano","orcid":"0000-0002-1413-0442","position":4,"is_corresponding":false},{"id":329464,"name":"Breton M. Asken","orcid":"0000-0001-8419-142X","position":5,"is_corresponding":false},{"id":329466,"name":"Corrina Fonseca","orcid":"0000-0002-4156-1037","position":6,"is_corresponding":false},{"id":642588,"name":"Frederike Cosima Oertel","orcid":"0000-0003-4906-5983","position":7,"is_corresponding":false},{"id":465094,"name":"Konstantinos Arfanakis","orcid":"0000-0001-9705-597X","position":8,"is_corresponding":false},{"id":260464,"name":"Adam M. Staffaroni","orcid":"0000-0002-3903-9805","position":9,"is_corresponding":false},{"id":253924,"name":"Joel H. Kramer","orcid":"0000-0002-2917-8297","position":10,"is_corresponding":false},{"id":347892,"name":"Michael D. Geschwind","orcid":"0000-0003-2861-3776","position":11,"is_corresponding":false},{"id":58513,"name":"Bruce L. Miller","orcid":"0000-0002-2152-4220","position":12,"is_corresponding":false},{"id":314700,"name":"Fanny M. Elahi","orcid":"0000-0003-4663-4992","position":13,"is_corresponding":false},{"id":246281,"name":"Ari Green","orcid":"0000-0001-9275-3066","position":14,"is_corresponding":false},{"id":926947,"name":"Ahmed Abdelhak","orcid":"0000-0001-9731-4169","position":0,"is_corresponding":true}],"reference_count":25,"raw_metadata":null,"created_at":"2026-07-19T00:29:52.825777Z","pmid":"35814617","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}