{"doi":"10.1002/dad2.12233","title":"Cortical thickness across the lifespan in a Colombian cohort with autosomal‐dominant Alzheimer's disease: A cross‐sectional study","abstract":"INTRODUCTION: Cortical thinning is a marker of neurodegeneration in Alzheimer's disease (AD). We investigated the age-related trajectory of cortical thickness across the lifespan (9-59 years) in a Colombian kindred with autosomal dominant AD (ADAD). METHODS: ] E280A mutation carriers, 16 with cognitive impairment; 106 non-carriers) underwent magnetic resonance imaging. A piecewise linear regression identified change-points in the age-related trajectory of cortical thickness in carriers and non-carriers. RESULTS: Unimpaired carriers exhibited elevated cortical thickness compared to non-carriers, and thickness more negatively correlated with age and cognition in carriers relative to non-carriers. We found increased cortical thickness in child carriers, after which thickness steadied compared to non-carriers prior to a rapid reduction in the decade leading up to the expected age at cognitive impairment in carriers. DISCUSSION: Findings suggest that cortical thickness may fluctuate across the ADAD lifespan, from early-life increased thickness to atrophy proximal to clinical onset.","journal":"Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring","year":2021,"id":200469,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.5036,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":448595,"name":"Heirangi Torrico‐Teave","orcid":null,"position":1,"is_corresponding":false},{"id":482787,"name":"Federico d’Oleire Uquillas","orcid":"0000-0001-9078-9452","position":2,"is_corresponding":false},{"id":226061,"name":"Kewei Chen","orcid":"0000-0001-8497-3069","position":3,"is_corresponding":false},{"id":255186,"name":"Yi Su","orcid":"0000-0002-1946-8063","position":4,"is_corresponding":false},{"id":255185,"name":"Yinghua Chen","orcid":"0000-0002-5020-7507","position":5,"is_corresponding":false},{"id":312880,"name":"Michael Brickhouse","orcid":null,"position":6,"is_corresponding":false},{"id":404056,"name":"Justin S. Sanchez","orcid":"0000-0003-4421-3078","position":7,"is_corresponding":false},{"id":778160,"name":"Cinthya Agüero","orcid":"0000-0001-9483-429X","position":8,"is_corresponding":false},{"id":263294,"name":"Heidi I.L. Jacobs","orcid":"0000-0001-7620-3822","position":9,"is_corresponding":false},{"id":458300,"name":"Olivia Hampton","orcid":null,"position":10,"is_corresponding":false},{"id":255190,"name":"Edmarie Guzmán‐Vélez","orcid":"0000-0002-3076-0727","position":11,"is_corresponding":false},{"id":255191,"name":"Clara Vila‐Castelar","orcid":"0000-0002-8779-1487","position":12,"is_corresponding":false},{"id":735240,"name":"Daniel Camilo Aguirre–Acevedo","orcid":"0000-0002-8195-8821","position":13,"is_corresponding":false},{"id":255197,"name":"Ana Baena","orcid":"0000-0002-5622-4519","position":14,"is_corresponding":false},{"id":454709,"name":"Arabiye Artola","orcid":"0000-0003-2358-8532","position":15,"is_corresponding":false},{"id":447836,"name":"Jairo E. Martínez","orcid":"0000-0002-5888-481X","position":16,"is_corresponding":false},{"id":737870,"name":"Celina F. Pluim","orcid":null,"position":17,"is_corresponding":false},{"id":656589,"name":"Sergio Álvarez","orcid":"0000-0003-4983-0892","position":18,"is_corresponding":false},{"id":656588,"name":"Martin Ochoa‐Escudero","orcid":"0000-0003-3933-3622","position":19,"is_corresponding":false},{"id":55006,"name":"Eric M. Reiman","orcid":"0000-0002-0705-3696","position":20,"is_corresponding":false},{"id":55000,"name":"Reisa A. Sperling","orcid":"0000-0003-1535-6133","position":21,"is_corresponding":false},{"id":226616,"name":"Francisco Lopera","orcid":"0000-0003-3986-1484","position":22,"is_corresponding":false},{"id":232961,"name":"Keith A. Johnson","orcid":"0000-0002-5916-6043","position":23,"is_corresponding":false},{"id":19606,"name":"Bradford C. Dickerson","orcid":"0000-0002-5958-3445","position":24,"is_corresponding":false},{"id":226624,"name":"Yakeel T. 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