{"doi":"10.1002/dad2.12091","title":"The temporal relationships between white matter hyperintensities, neurodegeneration, amyloid beta, and cognition","abstract":"INTRODUCTION: Cognitive decline in Alzheimer's disease is associated with amyloid beta (Aβ) accumulation, neurodegeneration, and cerebral small vessel disease, but the temporal relationships among these factors is not well established. METHODS: Data included white matter hyperintensity (WMH) load, gray matter (GM) atrophy and Alzheimer's Disease Assessment Scale-Cognitive-Plus (ADAS13) scores for 720 participants and cerebrospinal fluid amyloid (Aβ1-42) for 461 participants from the Alzheimer's Disease Neuroimaging Initiative. Linear regressions were used to assess the relationships among baseline WMH, GM, and Aβ1-42 to changes in WMH, GM, Aβ1-42, and cognition at 1-year follow-up. RESULTS: Baseline WMHs and Aβ1-42 predicted WMH increase and GM atrophy. Baseline WMHs and Aβ1-42 predicted worsening cognition. Only baseline Aβ1-42 predicted change in Aβ1-42. DISCUSSION: Baseline WMHs lead to greater future GM atrophy and cognitive decline, suggesting that WM damage precedes neurodegeneration and cognitive decline. Baseline Aβ1-42 predicted WMH increase, suggesting a potential role of amyloid in WM damage.","journal":"Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring","year":2020,"id":57677,"datarank":1.4591302707944789,"base_score":4.356708826689592,"endowment":4.356708826689592,"self_citation_contribution":0.6535063240034389,"citation_network_contribution":0.8056239467910401,"self_endowment_contribution":0.6535063240034389,"citer_contribution":0.8056239467910401,"corpus_percentile":85.75848998220778,"corpus_rank":1842,"citation_count":77,"citer_count":36,"citers_with_citation_signal":29,"citers_with_endowment":29,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":0.7799,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":264346,"name":"Richard Camicioli","orcid":"0000-0003-2977-8660","position":1,"is_corresponding":false},{"id":301641,"name":"Simon Duchesne","orcid":"0000-0002-6326-0745","position":2,"is_corresponding":false},{"id":194852,"name":"D. Louis Collins","orcid":"0000-0002-8432-7021","position":3,"is_corresponding":false},{"id":300139,"name":"for the Alzheimer's Disease Neuroimaging Initiative","orcid":null,"position":4,"is_corresponding":false},{"id":301640,"name":"Mahsa Dadar","orcid":"0000-0003-4008-2672","position":0,"is_corresponding":true}],"reference_count":53,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T21:06:48.611399Z","pmid":"33083512","pmcid":"PMC7552231","fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}