{"doi":"10.1002/dad2.12052","title":"Obesity impacts brain metabolism and structure independently of amyloid and tau pathology in healthy elderly","abstract":"AIMS/HYPOTHESIS: Midlife obesity is a risk factor for dementia. We investigated the impact of obesity on brain structure, metabolism, and cerebrospinal fluid (CSF) core Alzheimer's disease (AD) biomarkers in healthy elderly. METHODS: We selected controls from ADNI2 with CSF AD biomarkers and/or fluorodeoxyglucose positron emission tomography (FDG-PET) and 3T-MRI. We measured cortical thickness, FDG uptake, and CSF amyloid beta (Aβ)1-42, p-tau, and t-tau levels. We performed regression analyses between these biomarkers and body mass index (BMI). RESULTS: ). Higher BMI was related to less cortical thickness and higher metabolism in brain areas typically not involved in AD (family-wise error [FWE] <0.05), but not to AD CSF biomarkers. It is notable that the impact of obesity on brain metabolism and structure was also found in amyloid negative individuals. CONCLUSIONS/INTERPRETATION: In the cognitively unimpaired elderly, obesity has differential effects on brain metabolism and structure independent of an underlying AD pathophysiology.","journal":"Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring","year":2020,"id":77472,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":19,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9276,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":403868,"name":"Adriana Pané","orcid":"0000-0002-7810-1827","position":1,"is_corresponding":false},{"id":232592,"name":"Eduard Vilaplana","orcid":"0000-0002-1809-8435","position":2,"is_corresponding":false},{"id":232600,"name":"Víctor Montal","orcid":"0000-0002-5714-9282","position":3,"is_corresponding":false},{"id":304542,"name":"Alexandre Bejanin","orcid":"0000-0002-9958-0951","position":4,"is_corresponding":false},{"id":232595,"name":"Laura Videla","orcid":"0000-0002-9748-8465","position":5,"is_corresponding":false},{"id":232593,"name":"María Carmona‐Iragui","orcid":"0000-0001-6914-2339","position":6,"is_corresponding":false},{"id":232596,"name":"Isabel Barroeta","orcid":"0000-0003-2764-7923","position":7,"is_corresponding":false},{"id":403869,"name":"Ainitze Ibarzábal","orcid":"0000-0002-1220-6474","position":8,"is_corresponding":false},{"id":403870,"name":"Anna Casajoana","orcid":"0000-0003-2282-6965","position":9,"is_corresponding":false},{"id":232612,"name":"Daniel Alcolea","orcid":"0000-0002-3819-3245","position":10,"is_corresponding":false},{"id":232601,"name":"Sílvia Valldeneu","orcid":"0000-0003-3497-886X","position":11,"is_corresponding":false},{"id":232598,"name":"Miren Altuna","orcid":"0000-0001-9709-5314","position":12,"is_corresponding":false},{"id":403871,"name":"Ana de Hollanda","orcid":"0000-0001-9114-8614","position":13,"is_corresponding":false},{"id":251524,"name":"Josép Vidal","orcid":"0000-0002-4564-4518","position":14,"is_corresponding":false},{"id":403872,"name":"Emilio Ortega","orcid":"0000-0002-2217-8905","position":15,"is_corresponding":false},{"id":232608,"name":"Ricardo S. Osorio","orcid":"0000-0002-2735-9609","position":16,"is_corresponding":false},{"id":403873,"name":"Antonio Convit","orcid":"0000-0003-2201-2689","position":17,"is_corresponding":false},{"id":232614,"name":"Rafael Blesa","orcid":"0000-0003-4026-2884","position":18,"is_corresponding":false},{"id":27613,"name":"Alberto Lleó","orcid":"0000-0002-2568-5478","position":19,"is_corresponding":false},{"id":232591,"name":"Juan Fortea","orcid":"0000-0002-1340-638X","position":20,"is_corresponding":false},{"id":403874,"name":"Amanda Jiménez","orcid":"0000-0003-4967-1174","position":21,"is_corresponding":false},{"id":19445,"name":"Alzheimer's Disease Neuroimaging Initiative","orcid":null,"position":22,"is_corresponding":false},{"id":232599,"name":"Jordi Pegueroles","orcid":"0000-0002-3554-2446","position":0,"is_corresponding":true}],"reference_count":50,"raw_metadata":null,"created_at":"2026-07-18T21:49:16.197289Z","pmid":"32743041","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}