{"doi":"10.1002/dad2.12042","title":"BHA‐CS: A novel cognitive composite for Alzheimer's disease and related disorders","abstract":"INTRODUCTION: Composite scores based on psychometrically rigorous cognitive assessments are well suited for early diagnosis and disease monitoring. METHODS: We developed and cross-validated the Brain Health Assessment-Cognitive Score (BHA-CS), based on a brief computerized battery, in 451 cognitively normal (CN) and 399 cognitively impaired (mild cognitive impairment [MCI] or dementia) older adults. We investigated its long-term reliability and reliable change indices at longitudinal follow-up (N = 340), and the association with amyloid beta (Aβ) burden in the CN subgroup with Aβ positron emission tomography (N = 119). RESULTS: The BHA-CS was accurate at detecting cognitive impairment and exhibited excellent long-term stability. Reliable decline over one year was detected in 75% of participants with dementia, 44% with MCI, and 3% of CN. Among CN, the Aβ-positive group showed worse longitudinal performance on the BHA-CS compared to the Aβ-negative group. DISCUSSION: The BHA-CS is sensitive to cognitive decline in preclinical and prodromal neurodegenerative disease.","journal":"Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring","year":2020,"id":93325,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":40,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.934,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":68143,"name":"Sabrina J. Erlhoff","orcid":null,"position":1,"is_corresponding":false},{"id":466752,"name":"Collette A. Goode","orcid":null,"position":2,"is_corresponding":false},{"id":466753,"name":"Karen A. Dorsman","orcid":null,"position":3,"is_corresponding":false},{"id":466754,"name":"Suchanan Kanjanapong","orcid":null,"position":4,"is_corresponding":false},{"id":367338,"name":"Cutter A. Lindbergh","orcid":"0000-0002-9329-4663","position":5,"is_corresponding":false},{"id":260103,"name":"Renaud La Joie","orcid":"0000-0003-2581-8100","position":6,"is_corresponding":false},{"id":349416,"name":"Amelia Strom","orcid":null,"position":7,"is_corresponding":false},{"id":230947,"name":"Gil D. Rabinovici","orcid":"0000-0002-3626-4265","position":8,"is_corresponding":false},{"id":262283,"name":"Serggio Lanata","orcid":"0000-0002-2539-8575","position":9,"is_corresponding":false},{"id":58513,"name":"Bruce L. Miller","orcid":"0000-0002-2152-4220","position":10,"is_corresponding":false},{"id":465960,"name":"Sarah Tomaszewski Farias","orcid":"0009-0009-8969-3387","position":11,"is_corresponding":false},{"id":253924,"name":"Joel H. Kramer","orcid":"0000-0002-2917-8297","position":12,"is_corresponding":false},{"id":270253,"name":"Katherine P. Rankin","orcid":"0000-0002-3611-0848","position":13,"is_corresponding":false},{"id":465961,"name":"Katherine L. Possin","orcid":"0000-0002-6623-3793","position":14,"is_corresponding":false},{"id":367339,"name":"Elena Tsoy","orcid":"0000-0001-8786-1791","position":0,"is_corresponding":true}],"reference_count":46,"raw_metadata":null,"created_at":"2026-07-18T22:30:54.208860Z","pmid":"32582835","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}