{"doi":"10.1002/dad2.12039","title":"Proteomic profiles for Alzheimer's disease and mild cognitive impairment among adults with Down syndrome spanning serum and plasma: An Alzheimer's Biomarker Consortium–Down Syndrome (ABC–DS) study","abstract":"Introduction Previously generated serum and plasma proteomic profiles were examined among adults with Down syndrome (DS) to determine whether these profiles could discriminate those with mild cognitive impairment (MCI-DS) and Alzheimer's disease (DS-AD) from those cognitively stable (CS). Methods Data were analyzed on n = 305 (n = 225 CS; n = 44 MCI-DS; n = 36 DS-AD) enrolled in the Alzheimer's Biomarker Consortium–Down Syndrome (ABC–DS). Results Distinguishing MCI-DS from CS, the serum profile produced an area under the curve (AUC) = 0.95 (sensitivity [SN] = 0.91; specificity [SP] = 0.99) and an AUC = 0.98 (SN = 0.96; SP = 0.97) for plasma when using an optimized cut-off score. Distinguishing DS-AD from CS, the serum profile produced an AUC = 0.93 (SN = 0.81; SP = 0.99) and an AUC = 0.95 (SN = 0.86; SP = 1.0) for plasma when using an optimized cut-off score. AUC remained unchanged to slightly improved when age and sex were included. Eotaxin3, interleukin (IL)-10, C-reactive protein, IL-18, serum amyloid A , and FABP3 correlated fractions at r2 > = 0.90. Discussion Proteomic profiles showed excellent detection accuracy for MCI-DS and DS-AD.","journal":"Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring","year":2020,"id":105555,"datarank":0.6743952057211301,"base_score":3.1780538303479458,"endowment":3.1780538303479458,"self_citation_contribution":0.47670807455219194,"citation_network_contribution":0.19768713116893813,"self_endowment_contribution":0.47670807455219194,"citer_contribution":0.19768713116893813,"corpus_percentile":70.36435367834764,"corpus_rank":3832,"citation_count":23,"citer_count":8,"citers_with_citation_signal":7,"citers_with_endowment":7,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":0.7972,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":412178,"name":"Fan Zhang","orcid":"0000-0003-4692-0526","position":1,"is_corresponding":false},{"id":266059,"name":"Nicole Schupf","orcid":"0000-0001-7560-7657","position":2,"is_corresponding":false},{"id":270468,"name":"Sharon J. Krinsky‐McHale","orcid":"0000-0002-7205-7319","position":3,"is_corresponding":false},{"id":326972,"name":"James Hall","orcid":"0000-0002-8153-1537","position":4,"is_corresponding":false},{"id":80305,"name":"Mark Mapstone","orcid":"0000-0003-0280-8057","position":5,"is_corresponding":false},{"id":87920,"name":"Amrita K. Cheema","orcid":"0000-0003-4877-7583","position":6,"is_corresponding":false},{"id":270472,"name":"Wayne Silverman","orcid":"0000-0002-7842-8600","position":7,"is_corresponding":false},{"id":270460,"name":"Ira T. Lott","orcid":"0000-0002-3107-0752","position":8,"is_corresponding":false},{"id":34920,"name":"Michael S. Rafii","orcid":"0000-0003-2640-2094","position":9,"is_corresponding":false},{"id":270459,"name":"Benjamin L. Handen","orcid":"0000-0001-9550-1665","position":10,"is_corresponding":false},{"id":49958,"name":"William E. 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Ances","orcid":"0000-0003-3862-7397","position":18,"is_corresponding":false},{"id":270465,"name":"Mei‐Cheng Wang","orcid":"0000-0002-0460-7956","position":19,"is_corresponding":false},{"id":322446,"name":"Benjamin Tycko","orcid":"0000-0001-7811-5164","position":20,"is_corresponding":false},{"id":270463,"name":"Joseph H. Lee","orcid":"0000-0002-2000-4821","position":21,"is_corresponding":false},{"id":270462,"name":"Sid E. 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