{"doi":"10.1002/dad2.12035","title":"High blood pressure predicts hippocampal atrophy rate in cognitively impaired elders","abstract":"INTRODUCTION: Understanding relationships among blood pressure (BP), cognition, and brain volume could inform Alzheimer's disease (AD) management. METHODS: We investigated Alzheimer's Disease Neuroimaging Initiative (ADNI) participants: 200 controls, 346 mild cognitive impairment (MCI), and 154 AD. National Alzheimer's Co-ordinating Center (NACC) participants were separately analyzed: 1098 controls, 2297 MCI, and 4845 AD. Relationships between cognition and BP were assessed in both cohorts and BP and atrophy rates in ADNI. Multivariate mixed linear-regression models were fitted with joint outcomes of BP (systolic, diastolic, and pulse pressure), cognition (Mini-Mental State Examination, Logical Memory, and Digit Symbol) and atrophy rate (whole-brain, hippocampus). RESULTS: value]; 0.2, 0.005 and 0.2, 0.04, respectively). NACC AD patients with lower systolic BP had lower cognitive scores (0.1, 0.0003). DISCUSSION: Higher late-life BP may be associated with faster decline in cognitively impaired elders.","journal":"Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring","year":2020,"id":77968,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":18,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.7413,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":406190,"name":"Jennifer M. Nicholas","orcid":"0000-0001-6023-0391","position":1,"is_corresponding":false},{"id":363430,"name":"Geert Jan Biessels","orcid":"0000-0001-6862-2496","position":2,"is_corresponding":false},{"id":406191,"name":"Christopher Lane","orcid":"0000-0003-2945-9352","position":3,"is_corresponding":false},{"id":104558,"name":"M. Jorge Cardoso","orcid":"0000-0003-1284-2558","position":4,"is_corresponding":false},{"id":348762,"name":"Josephine Barnes","orcid":"0000-0003-3178-025X","position":5,"is_corresponding":false},{"id":348759,"name":"Cassidy M. Fiford","orcid":"0000-0002-0114-7800","position":0,"is_corresponding":true}],"reference_count":49,"raw_metadata":null,"created_at":"2026-07-18T21:49:40.769098Z","pmid":"32587882","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}