{"doi":"10.1002/dad2.12016","title":"In vivo network models identify sex differences in the spread of tau pathology across the brain","abstract":"INTRODUCTION: F]flortaucipir positron emission tomography (PET) uptake to evaluate sex-specific differences in brain-wide tau propagation. METHODS: PET data of clinically normal and mild cognitive impairment (MCI) subjects from the Alzheimer's Disease Neuroimaging Initiative (ADNI) were used to examine differences in network architectures across the groups. RESULTS: The tau-based network architecture resembled progression of tauopathy from Braak stage I to VI regions. Compared to men, women had higher network density and an increased number of direct regional connections in co-occurrence with increased brain-wide tau burden, particularly at MCI. Several regions, including superior parietal lobe and parahippocampus served as connecting bridges between communities at different Braak stages. DISCUSSION: Network characteristics in women may favor an accelerated brain-wide tau spread leading to a higher tau burden in women than men with MCI with implications for the greater female preponderance in Alzheimer's disease diagnosis.","journal":"Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring","year":2020,"id":94709,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":37,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.7862,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":415599,"name":"Warren D. Taylor","orcid":"0000-0002-9975-3082","position":1,"is_corresponding":false},{"id":376067,"name":"Kimberly Albert","orcid":"0000-0002-1965-2899","position":2,"is_corresponding":false},{"id":274458,"name":"Hakmook Kang","orcid":"0000-0001-6876-4021","position":3,"is_corresponding":false},{"id":376070,"name":"Paul Newhouse","orcid":"0000-0002-9298-7185","position":4,"is_corresponding":false},{"id":29928,"name":"the Alzheimer's Disease Neuroimaging Initiative","orcid":null,"position":5,"is_corresponding":false},{"id":376069,"name":"Sepideh Shokouhi","orcid":"0000-0001-6904-1861","position":0,"is_corresponding":true}],"reference_count":52,"raw_metadata":null,"created_at":"2026-07-18T22:33:00.770265Z","pmid":"32280740","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}