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Moreover, a special focus is placed on the functions of mitochondrial rRNA modifications and their aberrant expression in cancer, an area with profound implications yet largely uncharted. Dysregulation in these modifications can lead to metabolic dysfunction and apoptosis resistance, hallmark traits of cancer cells. Furthermore, the current challenges and future perspectives in targeting rRNA modifications are highlighted as a therapeutic approach for cancer treatment. In conclusion, rRNA modifications represent a frontier in cancer research, offering novel insights and therapeutic possibilities. Understanding and harnessing these modifications can pave the way for breakthroughs in cancer treatment, potentially transforming the approach to combating this complex disease.</jats:p>","journal":"Clinical and Translational Medicine","year":2024,"id":608921,"datarank":0.7005635369599272,"base_score":3.295836866004329,"endowment":3.295836866004329,"self_citation_contribution":0.4943755299006494,"citation_network_contribution":0.2061880070592778,"self_endowment_contribution":0.4943755299006494,"citer_contribution":0.2061880070592778,"corpus_percentile":null,"corpus_rank":null,"citation_count":26,"citer_count":24,"citers_with_citation_signal":16,"citers_with_endowment":16,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1564539,"name":"Jiarong Zheng","orcid":null,"position":1,"is_corresponding":false},{"id":1564540,"name":"Yunfan Lin","orcid":null,"position":2,"is_corresponding":false},{"id":13738,"name":"Pei Lin","orcid":"0000-0001-8493-3294","position":3,"is_corresponding":false},{"id":1444486,"name":"Ye Lu","orcid":"0000-0003-1113-3709","position":4,"is_corresponding":false},{"id":1564541,"name":"Yucheng Zheng","orcid":null,"position":5,"is_corresponding":false},{"id":615890,"name":"Bing Guo","orcid":"0000-0002-3998-5981","position":6,"is_corresponding":false},{"id":1564542,"name":"Xinyuan Zhao","orcid":"0000-0003-4770-8877","position":7,"is_corresponding":false},{"id":910559,"name":"Li Cui","orcid":"0000-0002-4125-2138","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Decoding the ribosome's hidden language: rRNA modifications as key players in cancer dynamics and targeted therapies","abstract":"<jats:title>Abstract</jats:title><jats:p>Ribosomal RNA (rRNA) modifications, essential components of ribosome structure and function, significantly impact cellular proteomics and cancer biology. 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