{"doi":"10.1002/cpt1976193300","title":"Influence of cannabidiol on delta‐9‐tetrahydrocannabinol effects","abstract":"<jats:p>Experiments investigating the possible interaction of tetrahydrocannabinol (THC) and cannabidiol (CBD), two major components of marihuana, were conducted under controlled laboratory conditions in a double‐blind manner. In one study, 15 male volunteers were given placebo or 25 µg/kg of THC together with either placebo or 150 µg/kg of CBD by inhalation of the smoke of a single cigarette. All four treatments were assigned to each subject according to a series of Latin‐square designs. CBD significantly attenuated the subjective euphoria of THC. Psychomotor impairment due to THC was not significantly altered by the simultaneous administration of CBD, but a trend indicating a decrease in THC‐like effects was observed after the combination. When administered alone CBD was inactive for all the parameters measured. In a second study, 8 male subjects were given CBD (0 or 150 µg/kg) by smoke inhalation 30 min before THC (0 or 25 µg/kg) in a second cigarette. In contrast to the simultaneous administration of both drugs, CBD pretreatment did not alter the effects of THC on the parameters observed.</jats:p>","journal":"Clinical Pharmacology &amp; Therapeutics","year":1976,"id":40311,"datarank":6.955688961145299,"base_score":4.820281565605037,"endowment":4.820281565605037,"self_citation_contribution":0.7230422348407557,"citation_network_contribution":6.2326467263045435,"self_endowment_contribution":0.7230422348407557,"citer_contribution":6.2326467263045435,"corpus_percentile":null,"corpus_rank":null,"citation_count":123,"citer_count":121,"citers_with_citation_signal":106,"citers_with_endowment":106,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":196116,"name":"Robert Martz","orcid":null,"position":1,"is_corresponding":false},{"id":196117,"name":"Louis Lemberger","orcid":null,"position":2,"is_corresponding":false},{"id":196118,"name":"Bruce E. 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