{"doi":"10.1002/cpt.3747","title":"Impact of First‐of‐Its‐Kind Patient‐Facing Pharmacogenetics Tool on Dosing Decisions and Treatment Outcomes","abstract":"Germline pharmacogenetics (PGx) is increasingly used to tailor medication selection/dosing. However, existing systems primarily communicate PGx results to providers, limiting direct patient engagement. To address this, we developed YourPGx Oncology, an innovative patient-facing portal that delivers multi-gene PGx results (CYP2D6, UGT1A1, DPYD) through 33 unique, patient-friendly summaries. The utility of this tool was prospectively evaluated in an oncology population, where these pharmacogenes impact high-stakes treatments. Patients enrolled in the PhOCus study (NCT04541381) participated in single-session evaluations of the tool in-person or via videoconference, with a pharmacist available for questions and administering pre- and post-surveys that assessed educational impact. Each patient viewed their own previously obtained PGx results. Of 190 eligible patients, 70 responded to solicitations via email, phone, and in-person, of whom 51 (73%) completed an observed session and completed surveys. Patients spent a median of 13.4 minutes (range 8.1-21.0) navigating YourPGx Oncology. After portal interaction, patients' ability to identify individual efficacy and safety estimates for chemotherapies and pain medications significantly improved, with the proportion accurately recognizing PGx-informed drug efficacy likelihoods rising from 32% to 72% (Odds Ratio [OR] = 5.8 for the shift from discordant to concordant efficacy knowledge, P < 0.001), and PGx-related toxicity recognition increasing from 31% to 57% (OR = 3.2, P = 0.01). Our findings show that a customized patient-facing PGx results portal enhances patient understanding of individual medication efficacy and toxicity likelihoods, highlighting the potential key role of direct-to-patient PGx tools to facilitate optimized treatment-informed care and promote genetically guided shared decision-making.","journal":"Clinical Pharmacology & Therapeutics","year":2025,"id":569316,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9487,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1474549,"name":"Sami Elahi","orcid":null,"position":1,"is_corresponding":false},{"id":1450835,"name":"Matthew Jack","orcid":"0000-0003-1248-8851","position":2,"is_corresponding":false},{"id":6486,"name":"John Campbell","orcid":"0000-0002-6752-3493","position":3,"is_corresponding":false},{"id":1474242,"name":"Emily Smith","orcid":"0000-0002-1916-0843","position":4,"is_corresponding":false},{"id":783838,"name":"Randall W. Knoebel","orcid":"0000-0002-0166-4955","position":5,"is_corresponding":false},{"id":756676,"name":"David L. George","orcid":null,"position":6,"is_corresponding":false},{"id":755995,"name":"Larry House","orcid":"0000-0003-2066-9855","position":7,"is_corresponding":false},{"id":396012,"name":"Kiang-Teck J Yeo","orcid":"0000-0002-4708-8420","position":8,"is_corresponding":false},{"id":51395,"name":"Theodore Karrison","orcid":"0009-0009-8641-5111","position":9,"is_corresponding":false},{"id":85410,"name":"Samuel L. Volchenboum","orcid":"0000-0001-9863-851X","position":10,"is_corresponding":false},{"id":307481,"name":"David O. Meltzer","orcid":"0000-0003-2790-7393","position":11,"is_corresponding":false},{"id":569785,"name":"Russell Z. Szmulewitz","orcid":"0000-0002-1444-3617","position":12,"is_corresponding":false},{"id":1543,"name":"Everett E. Vokes","orcid":"0000-0002-8645-8068","position":13,"is_corresponding":false},{"id":356678,"name":"Mark J. Ratain","orcid":"0000-0002-0938-4392","position":14,"is_corresponding":false},{"id":51075,"name":"Peter H. O’Donnell","orcid":"0000-0003-2650-0049","position":15,"is_corresponding":false},{"id":1308223,"name":"Youngwoo Cho","orcid":"0000-0002-1902-0381","position":0,"is_corresponding":true}],"reference_count":30,"raw_metadata":null,"created_at":"2026-07-19T02:56:59.652443Z","pmid":"40579854","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}