{"doi":"10.1002/cpt.2072","title":"Transdermal Testosterone Attenuates Drug‐Induced Lengthening of Both Early and Late Ventricular Repolarization in Older Men","abstract":"We have previously reported that transdermal testosterone attenuates drug‐induced QT interval lengthening in older men. However, it is unknown whether this is due to modulation of early ventricular repolarization, late repolarization, or both. In a secondary analysis of a prospective, randomized, double‐blind, placebo‐controlled three‐way crossover study, we determined if transdermal testosterone and oral progesterone attenuate drug‐induced lengthening of early and late ventricular repolarization, represented by the electrocardiographic measurements J‐T peak c and T peak ‐T end , respectively, as well as T peak ‐T end /QT, a measure of transmural dispersion of repolarization. Male volunteers ≥ 65 years of age ( n = 14) were randomized to receive transdermal testosterone 100 mg, oral progesterone 400 mg, or matching transdermal/oral placebo daily for 7 days. On the morning following the seventh day, subjects received intravenous ibutilide 0.003 mg/kg, after which electrocardiograms were performed serially. One subject was excluded due to difficulty in T‐wave interpretation. Pre‐ibutilide J‐T peak c was lower during the testosterone phase than during progesterone and placebo (216 ± 23 vs. 227 ± 28 vs. 227 ± 21 ms, P = 0.002). Maximum post‐ibutilide J‐T peak c was also lower during the testosterone phase (233 ± 22 vs. 246 ± 29 vs. 248 ± 23 ms, P < 0.0001). Pre‐ibutilide T peak ‐T end was not significantly different during the three phases, but maximum post‐ibutilide T peak ‐T end was lower during the testosterone phase (80 ± 12 vs. 89 ± 18 vs. 86 ± 15 ms, P = 0.002). Maximum T peak ‐T end /QT was also lower during the testosterone phase (0.199 ± 0.023 vs. 0.216 ± 0.035 vs. 0.209 ± 0.031, P = 0.005). Progesterone exerted minimal effect on drug‐induced lengthening of J‐T peak c, and no effect on T peak ‐T end or T peak ‐T end /QT. Transdermal testosterone attenuates drug‐induced lengthening of both early and late ventricular repolarization in older men.","journal":"Clinical Pharmacology & Therapeutics","year":2020,"id":106700,"datarank":0.7181897364919851,"base_score":2.0794415416798357,"endowment":2.0794415416798357,"self_citation_contribution":0.31191623125197543,"citation_network_contribution":0.40627350524000966,"self_endowment_contribution":0.31191623125197543,"citer_contribution":0.40627350524000966,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":5,"citers_with_citation_signal":5,"citers_with_endowment":5,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9595,"is_data_producer":true,"deposit_databanks":{"ClinicalTrials.gov":["NCT02513940"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":417946,"name":"Heather A. Jaynes","orcid":"0000-0002-8517-5680","position":1,"is_corresponding":false},{"id":514515,"name":"Kevin M. Sowinski","orcid":"0000-0003-2897-9487","position":2,"is_corresponding":false},{"id":514516,"name":"Brian R. Overholser","orcid":"0000-0003-3055-9916","position":3,"is_corresponding":false},{"id":239730,"name":"Changyu Shen","orcid":"0000-0002-4444-0943","position":4,"is_corresponding":false},{"id":385534,"name":"Richard J. Kovacs","orcid":"0000-0001-7870-4313","position":5,"is_corresponding":false},{"id":514517,"name":"James E. Tisdale","orcid":"0000-0002-2117-9463","position":6,"is_corresponding":false},{"id":514514,"name":"Elena Tomaselli Muensterman","orcid":"0009-0007-8916-3680","position":0,"is_corresponding":true}],"reference_count":21,"raw_metadata":null,"created_at":"2026-07-18T23:12:31.053776Z","pmid":"33020898","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}